Infections in critically ill patients are associated with significant morbidity and mortality
whereby prompt administration of antimicrobials is crucial to help optimise treatment …

Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

Treatment of infections among critically ill patients remains problematic, with ongoing
challenges in antimicrobial dosing optimisation. Strategies, such as modelinformed …

Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

Introduction Broad-spectrum antibiotics such as beta-lactams and vancomycin are frequently
used to treat critically ill patients, however, a significant number do not achieve target …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

We would like to thank Liebchen et al.[1] for their comments on our article.[2] Furthermore,
we would like to thank Cotta and colleagues, who wrote a relevant editorial regarding the …

When antimicrobial therapy is prescribed in the intensive care unit (ICU), it is currently
common practice to utilize standard or nomogram dosing regimens for most antimicrobials …

Therapeutic drug monitoring (TDM) of antibiotics is recommended and increasingly used in
critically ill patients to optimize target attainment and account for interpatient …

Optimising antimicrobial dosing for critically ill patients is highly challenging and when it is
not achieved can lead to worse patient outcomes. To this end, use of dosing regimens …