[HTML][HTML] MicroRNA-138 overexpression alters Aβ42 levels and behavior in wildtype mice
E Boscher, C Goupil, S Petry, R Keraudren… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
changes in cognitive and behavioral functions. With the exception or rare mutations in PSEN …
changes in cognitive and behavioral functions. With the exception or rare mutations in PSEN …
miR-30a-5p induces Aβ production via inhibiting the nonamyloidogenic pathway in Alzheimer's disease
T Sun, K Zhao, M Liu, Z Cai, L Zeng, J Zhang… - Pharmacological …, 2022 - Elsevier
Alzheimer's disease (AD) pathogenesis is known to involve a dysregulation of microRNA
expression, and these intricate transcriptional cascades between multiple pathological …
expression, and these intricate transcriptional cascades between multiple pathological …
MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's …
Abstract Introduction and Aims Alzheimer's disease (AD) is characterized by the abnormal
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …
[HTML][HTML] microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice
J Hernandez-Rapp, S Rainone, C Goupil, V Dorval… - Scientific reports, 2016 - nature.com
The abnormal regulation of amyloid-β (Aβ) metabolism (eg, production, cleavage,
clearance) plays a central role in Alzheimer's disease (AD). Among endogenous factors …
clearance) plays a central role in Alzheimer's disease (AD). Among endogenous factors …
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor …
WX Wang, BW Rajeev, AJ Stromberg… - Journal of …, 2008 - Soc Neuroscience
MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene
regulation in a sequence-specific manner. However, little is understood about the role (s) of …
regulation in a sequence-specific manner. However, little is understood about the role (s) of …
MiR-335-5p inhibits β-amyloid (Aβ) accumulation to attenuate cognitive deficits through targeting c-jun-N-terminal kinase 3 in Alzheimer's disease
D Wang, Z Fei, S Luo, H Wang - Current neurovascular …, 2020 - ingentaconnect.com
Objective: Alzheimer's disease (AD), also known as senile dementia, is a common
neurodegenerative disease characterized by progressive cognitive impairment and …
neurodegenerative disease characterized by progressive cognitive impairment and …
Retracted: MiR‐485‐3p serves as a biomarker and therapeutic target of Alzheimer's disease via regulating neuronal cell viability and neuroinflammation by targeting …
L Yu, H Li, W Liu, L Zhang, Q Tian… - Molecular genetics & …, 2021 - Wiley Online Library
Abstract Background Numerous microRNAs (miRNAs) have been identified as functional
molecules in Alzheimer's disease (AD) pathogenesis. This study aimed to investigate the …
molecules in Alzheimer's disease (AD) pathogenesis. This study aimed to investigate the …
[HTML][HTML] The microRNA-455 null mouse has memory deficit and increased anxiety, targeting key genes involved in Alzheimer's disease
TE Swingler, L Niu, MG Pontifex, D Vauzour… - International journal of …, 2022 - mdpi.com
The complete molecular mechanisms underlying the pathophysiology of Alzheimer's
disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a …
disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a …
miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors
Y Xu, P Chen, X Wang, J Yao, S Zhuang - Neuroscience Letters, 2018 - Elsevier
Abstract MicroRNA (miR)-34a was recently determined to contribute to the pathological
development of Alzheimer's disease (AD). miR-34a deficiency significantly attenuates …
development of Alzheimer's disease (AD). miR-34a deficiency significantly attenuates …
MicroRNA-128 knockout inhibits the development of Alzheimer's disease by targeting PPARγ in mouse models
Y Liu, Y Zhang, P Liu, H Bai, X Li, J Xiao, Q Yuan… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a great threat for the health and life of elderly people. MicroRNA-
128 (miR-128) has been reported to be abnormally expressed in the brain of AD patients …
128 (miR-128) has been reported to be abnormally expressed in the brain of AD patients …