Chronic myeloid leukemia provides an illustrative disease model for both molecular
pathogenesis of cancer and rational drug therapy. Chronic myeloid leukemia is a clonal …

Chronic myelogenous leukemia is a clonal hematopoietic stem disorder characterized by
excess numbers of myeloid cells that over time, lose the capacity for terminal differentiation …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease caused by
recombination between the BCR gene on chromosome 22 and the ABL1 gene on …

Purpose of review In this review, we emphasize up-to-date practical cytogenetic and
molecular aspects of chronic myeloid leukemia (CML) and summarize current knowledge on …

Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive
accumulation of clonal myeloid (precursor) cells in hematopoietic tissues. CML cells display …

Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

Chronic myelogenous leukemia (CML) is one of the most frequently diagnosed forms of
leukemia. Recent advances in the understanding of the molecular mechanisms involved in …

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that follows a
characteristic clinical course in which a chronic phase of variable duration precedes an …

Chronic myelogenous leukemia (CML) begins as an indolent disease in which the myeloid
lineages in the bone marrow and blood gradually expand. Untreated, this chronic phase of …

Chronic myeloid leukaemia (CML) is a clonal disorder of the pluripotent haematopoietic
stem cell. The typical triphasic course of CML starts with the premalignant chronic phase …