Platinum compounds are the major group of metal-based chemotherapeutic drug used in
current practice and still a topic of intense investigation. The relative contribution of …

Abstract cis-Dichlorodiamminoplatinum-II (cis-DDP) has been widely used as an anticancer
chemotherapeutic agent. The mutagenicity of (cis-DDP) was investigated in vitro and in vivo …

HeLa S‐3 cells were treated with 195mPt‐radiolabeled cis‐diamminedichloroplatinum
(II)(CDDP) under various conditions, and the relationship between lethal effect and the …

Revised Manuscript Received April 21, 1995® abstract; We have studied the formation of
adducts upon carboplatin treatment of isolated DNA and in cells. The major adduct formedin …

Damage to mitochondrial DNA (mtDNA) has been postulated to be associated with aging,
cancer, and other chronic degenerative diseases which are the predominant causes of …

In order better to understand the factors that determine the sensitivity of human cells to the
antitumor agent cisplatin, we evaluated the capacity of human cells to recover from the …

Female LOU/M rats, bearing either a cisplatin (cisDDP)-sensitive or-resistant IgM
immunocytoma, were sacrificed at 1 or 24 h after cisDDP administration (iv, 10 mg/kg of …

The cytotoxic effects of cis-diamminedichloroplatinum (II)(cis-DDP) were shown to be
strongly potentiated by hyperthermia. The molecular mechanisms responsible for this …

To study mechanisms underlying resistance to cis-diamminedichloroplatinum (II)(cis-DDP)
we have induced resistance to this agent in BE human colon carcinoma cells. A 5-fold …

The mitochondrial toxicity of nucleoside reverse transcriptase inhibitors (NRTIs) is due to the
inhibition of mitochondrial DNA (mtDNA) polymerase γ (Pol γ), resulting in a blockade of …