The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer
Background After long-term androgen deprivation therapy, 25–30% prostate cancer (PCa)
acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key …
acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key …
[HTML][HTML] Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension
Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a
transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in …
transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in …
Up regulation of the Hippo signalling effector YAP1 is linked to early biochemical recurrence in prostate cancers
A Marx, A Schumann, D Höflmayer, E Bady… - Scientific Reports, 2020 - nature.com
The transcriptional coactivator YAP1 controls the balance between cell proliferation and
apoptosis. YAP1 overexpression is linked to poor prognosis in many cancer types, yet its …
apoptosis. YAP1 overexpression is linked to poor prognosis in many cancer types, yet its …
The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells
Yes-associated protein (YAP) is an effector of the Hippo tumor suppressor pathway. The
functional significance of YAP in prostate cancer has remained elusive. In this study, we first …
functional significance of YAP in prostate cancer has remained elusive. In this study, we first …
Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC) is a rare but aggressive histologic variant of
prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC …
prostate cancer that responds poorly to androgen deprivation therapy. Hybrid NEPC …
YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer
The transcriptional co-activator Yes-associated protein 1 (YAP1), a key nuclear effector of
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …
YAP1 is involved in tumorigenic properties of prostate cancer cells
Abstract The Yes Associated Protein 1 (YAP1) is a transcriptional cofactor negatively
regulated by Hippo Pathway. The dysregulation of the pathway has been shown to have a …
regulated by Hippo Pathway. The dysregulation of the pathway has been shown to have a …
Emerging role of YAP and the Hippo pathway in prostate cancer
F Koinis, E Chantzara, M Samarinas, A Xagara… - Biomedicines, 2022 - mdpi.com
The Hippo pathway regulates and contributes to several hallmarks of prostate cancer (PCa).
Although the elucidation of YAP function in PCa is in its infancy, emerging studies have shed …
Although the elucidation of YAP function in PCa is in its infancy, emerging studies have shed …
YAP is closely correlated with castration-resistant prostate cancer, and downregulation of YAP reduces proliferation and induces apoptosis of PC-3 cells
X Sheng, WB Li, DL Wang… - Molecular …, 2015 - spandidos-publications.com
Yes-associated protein 65 (YAP65) has been implicated as an oncogene, and its expression
is increased in human cancer. Previous studies have demonstrated that alterations in YAP …
is increased in human cancer. Previous studies have demonstrated that alterations in YAP …
Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder
JY Liu, YH Li, HX Lin, YJ Liao, SJ Mai, ZW Liu… - BMC cancer, 2013 - Springer
Background Yes-associated protein 1 (YAP 1), the nuclear effector of the Hippo pathway, is
a key regulator of organ size and a candidate human oncogene in multiple tumors …
a key regulator of organ size and a candidate human oncogene in multiple tumors …
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