The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis

KC O'connor, A Bar-Or, DA Hafler - Journal of clinical immunology, 2001 - Springer
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system white
matter. The association of the disease with MHC genes, the inflammatory white matter …

Immunopathogenesis of multiple sclerosis: the role of T cells

G Martino, HP Hartung - Current opinion in neurology, 1999 - journals.lww.com
Multiple sclerosis is considered to be an autoimmune disease that results from aberrant
immune responses to central nervous system antigens. T cells are considered to be crucial …

Immune regulation of multiple sclerosis

HP Hartung, O Aktas, T Menge, BC Kieseier - Handbook of clinical …, 2014 - Elsevier
Multiple sclerosis (MS) is considered a prototype inflammatory autoimmune disorder of the
central nervous system (CNS). The etiology of this disease remains unknown, but an …

Pathogenic mechanisms associated with different clinical courses of multiple sclerosis

H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

Insights into the immunopathogenesis of multiple sclerosis

N Hellings, J Raus, P Stinissen - Immunologic research, 2002 - Springer
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS). Significant progress has been made in our understanding of the etiology of MS. MS …

Immunopathogenesis of multiple sclerosis

M Comabella, SJ Khoury - Clinical immunology, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by
autoimmune inflammation, demyelination, and axonal damage. MS etiology remains …

Immunopathogenesis of multiple sclerosis

SM Agrawal, VW Yong - International review of neurobiology, 2007 - Elsevier
Multiple sclerosis (MS) is considered an immune‐mediated disorder in which immune cells
cross the blood–brain barrier to enter the central nervous system (CNS) wherein they …

Pathology and pathogenesis of demyelinating diseases

M Storch, H Lassmann - Current opinion in neurology, 1997 - journals.lww.com
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system of
putative autoimmune origin. In the present review the hypothesis that autoimmunity against …

Immunology of multiple sclerosis.

KC Williams, E Ulvestad, WF Hickey - Clinical neuroscience (New …, 1994 - europepmc.org
Multiple sclerosis (MS), a putative autoimmune disease of unknown etiology, is
characterized by CNS perivascular inflammation, foci of demyelination, and elevated …

Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies

P Stinissen, J Raus, J Zhang - Critical Reviews™ in …, 1997 - dl.begellhouse.com
Accumulating evidence indicates that multiple sclerosis (MS) is an autoimmune disease
mediated by autoreactive T lymphocytes with specificity for myelin antigens. Initially, the …