BACKGROUND Optic pathway glioma (OPG) is a prevalent tumor affecting children with
Neurofibromatosis type 1 (NF1), representing a diagnostic hallmark. OPGs, typically WHO …

BACKGROUND Treatment and clinical management decisions for children with NF1-OPGs
remain challenging as most existing data are retrospective and have not included …

INTRODUCTION Because treatment and clinical management decisions for children with
NF1-OPG remain challenging, we sought to establish evidence-based guidelines. We …

Neurofibromatosis type 1 (NF1)-associated optic pathway gliomas (NF1-OPG) is the chief
medical problem of patients with NF1 during childhood. These low-grade gliomas tend to …

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition that is the most
common inherited tumor predisposition syndrome with an incidence of 1: 3000 births. 1 …

Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1
(NF1), leading to visual deficits in fewer than half of these individuals. The goal of …

Methods Eleven-year retrospective chart review of all patients with a diagnosis of NF-1 (ICD-
9 237.7) and optic nerve glioma (ICD-9 192.0) at a single, tertiary care center. Data …

Screening studies have shown detection of optic pathway gliomas (OPGs) in 8 to 31% of
children with neurofibromatosis type 1 (NF1). Many of those affected show prolonged …

Objective To evaluate the utility of screening brain/orbital magnetic resonance imaging
(MRI) in a large population of children with neurofibromatosis type 1 (NF1) over a 20-year …

Abstract Background Optic pathway gliomas (OPGs) are present in 20% of children with
neurofibromatosis 1 (NF1) but are less frequently observed in adults. Our goal was to …