Introduction: Co-resistance to quinolones among extended spectrum β [1] lactamase (ESBL)-
producing E. coli commonly occurs in clinical settings. Quinolones act on DNA gyrase and …

Sixty-five ciprofloxacin-resistant clinical Escherichia coli isolates were collected from a
Taiwan Medical Center from December 1998 to February 1999. All 65 clinical isolates were …

Extensive use of fluoroquinolone antibacterial in clinical practice has been associated with
increasing frequency of quinolone-resistant Escherichia coli strains. In the current study, a …

Since the use of fluoroquinolone antibiotic in clinical practice was introduced about two
decades ago, quinolone-resistant E. coli strains are being isolated with increasing …

Plasmid-mediated quinolone resistance mechanisms in extended spectrum beta-lactamase
positive and quinolone resistant Escherichia coli and Klebsiella pneumoniae strains isolated …

Antimicrobial resistance is a serious problem on the ascendency which has been
documented in some parts of Africa and Ghana. By the World Health Organization's …

Klebsiella pneumoniae is a typical pathogen in urinary tract infections (UTI), and the
emergence of extended spectrum beta-lactamase (ESBL)-producing strains has been …

Introduction: Resistance to fluoroquinolones is mainly due to point mutations that gave rise
to amino acid substitutions in the quinolone resistance-determining regions of either gyrA or …

The most important of fluoroquinolones resistance mechanisms is the accumulation of
mutations in the bacterial enzymes targeted by fluoroquinolones; DNA gyrase and DNA …

Therapeutic options with quinolones are severely compromised in infections caused by
members of Enterobacteriaceae family. Mutations in chromosomal region are one of the …