Towards a vaccine against Plasmodium vivax malaria

JG Beeson, BS Crabb - PLoS Medicine, 2007 - journals.plos.org
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Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein

E Chen, ND Salinas, Y Huang… - Proceedings of the …, 2016 - National Acad Sciences
Plasmodium vivax Duffy Binding Protein (PvDBP) is the most promising vaccine candidate
for P. vivax malaria. The polymorphic nature of PvDBP induces strain-specific immune …

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical …

WQ He, AR Shakri, R Bhardwaj… - PLoS neglected …, 2019 - journals.plos.org
Background The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of
naturally acquired immunity. However, region II of PvDBP, which contains the receptor …

Identification and evaluation of universal epitopes in Plasmodium vivax Duffy binding protein

C Saravia, P Martinez, DS Granados, C Lopez… - Biochemical and …, 2008 - Elsevier
Selected PvDBP-derived synthetic peptides were tested in competition assays with HLA
molecules in order to identify and evaluate their binding to a wide range of MHC class II …

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody

TA Rawlinson, NM Barber, F Mohring, JS Cho… - Nature …, 2019 - nature.com
The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this
parasite must invade immature red blood cells through a process requiring interaction of the …

Immunogenicity of a Plasmodium vivax vaccine based on the duffy binding protein formulated using adjuvants compatible for use in humans

FJ Martinez, M Guillotte-Blisnick, C Huon, P England… - Scientific Reports, 2023 - nature.com
The invasion of reticulocytes by Plasmodium vivax merozoites is dependent on the
interaction of the Plasmodium vivax Duffy Binding Protein (PvDBP) with the Duffy antigen …

Preclinical assessment of the receptor-binding domain of Plasmodium vivax Duffy-binding protein as a vaccine candidate in rhesus macaques

A Moreno, I Caro-Aguilar, SS Yazdani, AR Shakri… - Vaccine, 2008 - Elsevier
The receptor-binding domain of Plasmodium vivax Duffy-binding protein, region II (PvRII), is
an attractive candidate for a vaccine against P. vivax malaria. Here, we have studied the …

Immunogenicity and protective efficacy of recombinant vaccine based on the receptor-binding domain of the Plasmodium vivax Duffy binding protein in Aotus monkeys

M Arevalo-Herrera, A Castellanos… - … American journal of …, 2005 - repository.ias.ac.in
Invasion of human erythrocytes by Plasmodium vivax requires interaction between Duffy
binding protein (PvDBP) and the Duffy blood group antigen. The receptor-binding domain of …

[PDF][PDF] Serologic responses to recombinant Plasmodium vivax Duffy binding protein in a Colombian village.

PA Michon, M Arevalo-Herrera, T Fraser… - The American journal …, 1998 - researchgate.net
The Plasmodium vivax Duffy binding protein (DBP) is essential during merozoite invasion
into human erythrocytes. Because of its biological importance, the DBP is also seen to have …

Naturally Acquired and Vaccine-Elicited Antibodies Block Erythrocyte Cytoadherence of the Plasmodium vivaxDuffy Binding Protein

P Michon, T Fraser, JH Adams - Infection and immunity, 2000 - Am Soc Microbiol
Malaria merozoites require the presence of specific surface receptors on the red blood cell
for invasion. Plasmodium vivax, requires the Duffy blood group antigen as an obligate …