Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin

SN Huang, MA Phelps, PW Swaan - Journal of Pharmacology and …, 2003 - ASPET
Previous studies by our laboratory have suggested the potential role of receptor-mediated
endocytosis components in the cellular translocation of riboflavin (vitamin B2). To delineate …

Involvement of a receptor-mediated component in cellular translocation of riboflavin

SN Huang, PW Swaan - Journal of Pharmacology and Experimental …, 2000 - ASPET
This study addresses the transport mechanism of riboflavin (vitamin B2) across intestinal
epithelium in the presence and absence of pharmacologically active compounds. A …

Current perspectives on the cellular uptake and trafficking of riboflavin

AB Foraker, CM Khantwal, PW Swaan - Advanced drug delivery reviews, 2003 - Elsevier
The role of riboflavin in cell maintenance and growth, and the mechanism by which it is
absorbed into various human tissues and cell lines has been extensively studied over the …

Riboflavin-mediated delivery of a macromolecule into cultured human cells

SR Holladay, Z Yang, MD Kennedy, CP Leamon… - … et Biophysica Acta (BBA …, 1999 - Elsevier
Cell surface receptors for the vitamins folic acid and biotin have been previously reported to
mediate the endocytosis of vitamin-conjugated macromolecules into cultured cells. To …

A novel rhodamine− riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization …

MA Phelps, AB Foraker, W Gao, JT Dalton… - Molecular …, 2004 - ACS Publications
Riboflavin (vitamin B2, RF) is taken up in eukaryotic cells via specialized transport
mechanisms. Although RF has fluorescence properties, direct microscopic visualization of …

Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …

Identification and functional characterization of riboflavin transporter in human-derived retinoblastoma cell line (Y-79): mechanisms of cellular uptake and translocation

V Kansara, D Pal, R Jain, AK Mitra - Journal of Ocular Pharmacology …, 2005 - liebertpub.com
Drug delivery to the retina is a challenging task owing to its complex physiology and
presence of the blood-retinal barrier (BRB), which regulates the permeation of substances …

Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells

M Patel, RK Vadlapatla, D Pal, AK Mitra - Brain research, 2012 - Elsevier
Riboflavin is an important water soluble vitamin (B2) required for metabolic reactions,
normal cellular growth, differentiation and function. Mammalian brain cells cannot …

Identification of riboflavin transport by MDCK cells using quantitative fluorescence video microscopy

RJ Lowy, KR Spring - The Journal of membrane biology, 1990 - Springer
MDCK cells, when examined by low-light level video microscopy displayed an endogenous
fluorescence with two differing patterns. A low intensity emission which was punctate and …

Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier

Y Kubo, S Miki, S Akanuma, K Hosoya - Drug Metabolism and …, 2019 - Elsevier
The previous in vivo study revealed the carrier-mediated transport of riboflavin (vitamin B 2)
across the blood-retinal barrier (BRB). In the present study, the blood-to-retina supply of …