BACKGROUND Medulloblastoma 5-years survival rates range from 50-95% across risk
classes, underscoring the need to mitigate treatment-related neurocognitive deficits. This …

PURPOSE: Children treated for medulloblastoma (MB) undergo intensive multimodality
treatment compromising surgery, irradiation, and chemotherapy, which is associated with a …

BACKGROUND Medical and treatment variables, including presence of post-operative
cerebellar mutism syndrome (CMS), shunt placement, craniospinal radiation, and total …

Pupose Medulloblastoma is the most common primary malignant central nervous system
tumor in childhood, accounting for 16–25% of cases (1). New treatment approaches have …

Long-term neurocognitive difficulties in children treated for a brain tumor are well
documented and known to be affected by treatment. However, longitudinal studies of these …

Purpose/Objective (s) To characterize the association between neurocognitive outcomes
and radiation dose to the corpus callosum and the hippocampus in children with …

OBJECTIVES Reduced neuropsychological outcomes are a major concern in pediatric
patients with malignant brain tumors. We aimed to estimate decline in cognitive function …

OBJECTIVE Pediatric brain tumor survivors (PBTS) are at risk for developing neurocognitive
late effects that may interfere with academic and adaptive functioning. To mitigate the …

Purpose To evaluate intellectual functioning and the implications of limiting radiation
exposure in the four biologically distinct subgroups of medulloblastoma: wingless (WNT) …

Objective Risk-adapted treatment approaches employed within contemporary
medulloblastoma treatment protocols aim to reduce the neurotoxicity directed at the central …