Serum leptin, a polypeptide hormone secreted primarily by adipocytes, is a reflection of
somatic fat availability in humans and other vertebrates. Among Ache Amerindians, leptin …

The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not
clear. Recently published genome‐wide association (GWA) studies of the general …

Plasma leptin concentrations are markedly reduced in malnourished patients with anorexia
nervosa (AN). Whether the long-term underweight and low-fat stores affect the leptin …

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

Leptin is an adipocyte-derived signal factor (167 amino acid protein) encoded by the ob
gene in chromosome 7q31 that regulates eating behaviour via central neuroendocrine …

Psychometrically defined restrained eaters consume fewer calories, take fewer meals, show
higher preference for low calorie foods, have lower energy expenditure and a higher rate of …

Background Ghrelin and leptin are both peptide hormones and act as opposing players in
the regulation of hunger, satiety and energy expenditure. Leptin reduces appetite and …

Introduction: Human and animal studies provide evidence for a relevant role of the leptin
receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy …

Homozygosity for pathogenic variants in the leptin gene leads to congenital leptin deficiency
causing severe early-onset obesity. This monogenic form of obesity has mainly been …

Objective Relapse after weight restoration in anorexia nervosa (AN) is a critical problem.
Higher body fat percentage after weight gain has been shown to predict better weight …