Objectives Leptin polymorphism (LEP) has been associated with coronary heart disease
(CAD), obesity, and high body mass index (BMI). However, we performed a systematic …

Background Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin
with its receptor, leading to extreme early-onset obesity. The purpose of this work was to …

The leptin receptor (LEPR) is associated with insulin resistance, a key feature of metabolic
syndrome (MetS). Gene-fatty acid interactions may affect MetS risk. The objective was to …

Objective: To determine if levels of the adipocyte-derived hormone, leptin, predict the
development of type 2 diabetes. Methods: Population-based surveys were undertaken in the …

Objectives: Leptin is a crucial regulator of energy balance and is associated with obesity. In
recent years, it has also been recognized as involved in the psychopathological mechanism …

Background Even though the evidence supporting the presence of a heritable component in
the aetiology of anorexia nervosa (AN) is strong, the underlying genetic mechanisms remain …

Background: Obesity and being overweight have been described as potential causes of
neurological disorders. Leptin, a peptide expressed in fat tissue, importantly participates in …

Introduction Leptin (LEP) gene is one of the most promising candidate genes for obesity.
Previous studies have tested the association of polymorphisms in LEP gene with obesity …

Hypoleptinemia is a key endocrinological feature of anorexia nervosa (AN). Several
symptoms in acute AN are related to the low circulating leptin levels including amenorrhea …

Case studies of patients with anorexia nervosa revealed psychological improvements upon
treatment with recombinant human leptin, including an alleviation of the entrapment in this …