Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc ( Min/+ ) colon epithelial cell line

JI Fenton, SD Hursting, SN Perkins, NG Hord - Carcinogenesis, 2006 - academic.oup.com
Increased visceral adipose tissue results in elevated plasma leptin, which are associated
with increased risk of a number of obesity-related cancers. However, research is …

Leptin and colorectal cancer: an undefined link

ML Slattery, RK Wolff - Nature Clinical Practice Gastroenterology & …, 2007 - nature.com
Leptin is involved in many biological processes that implicate it in the development of
colorectal cancer. This Viewpoint discusses the biological plausibility of a relationship …

Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites

G Mantovani, A Macciò, L Mura, E Massa… - Journal of Molecular …, 2000 - Springer
Leptin is a recently identified hormone produced by the adipocyte ob gene which acts as a
negative feedback signal critical to the normal control of food intake and body weight. A …

[HTML][HTML] The role of leptin in cancer pathogenesis

I Tourkantonis, M Kiagia, E Peponi, S Tsagouli… - 2013 - scirp.org
Leptin is a hormone produced and secreted by adipose tissue. It is a member of adipokine
family with a principal role in body weight regulation. It is reported that low brain leptin levels …

Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer

X Zhao, K Huang, Z Zhu, S Chen… - … of gastroenterology and …, 2007 - Wiley Online Library
Background: The relationship between the expression of leptin in the tissue of gastric cancer
and the clinicopathological features as well as patients' outcome were investigated …

[HTML][HTML] Prognostic significance of tissue leptin expression in colorectal cancer patients

WK Jeong, SK Baek, MK Kim, SY Kwon… - Annals of …, 2015 - ncbi.nlm.nih.gov
Purpose Leptin is encoded by the ob gene and is involved in the control of food intake and
energy expenditure. Recent studies have implicated leptin expression to be an indicator of …

The association of gastric leptin with oesophageal inflammation and metaplasia

F Francois, J Roper, AJ Goodman, Z Pei, M Ghumman… - Gut, 2008 - gut.bmj.com
Background: Gastro-oesophageal reflux disease complications may reflect imbalances
between protective and injurious factors. Through its effects on cell growth, leptin may …

Plasma concentration of total leptin and human lung-cancer-associated cachexia

JPFHA Simons, AMWJ Schols, LA Campfield… - Clinical …, 1997 - portlandpress.com
1. Adipocyte-derived leptin is postulated to represent the afferent hormonal signal to the
hypothalamus in a feedback mechanism that regulates fat mass. In this proposed feedback …

Leptin role in advanced lung cancer. A mediator of the acute phase response or a marker of the status of nutrition?

MR Alemán, F Santolaria, N Batista, MJ de La Vega… - Cytokine, 2002 - Elsevier
Leptin is an anorexia inductor peptide produced by adipocytes and related to fat mass.
Leptin is also produced by fat under proinflammatory cytokine action. Our objective is to …

Obesity and colon cancer: does leptin provide a link?

P Stattin, A Lukanova, C Biessy… - … journal of cancer, 2004 - Wiley Online Library
Obesity, a risk factor for colorectal cancer, is associated with elevated serum levels of leptin,
the adipocyte‐derived hormone, and insulin. Experimental and epidemiologic studies have …