Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery
remodelling leading to increased right ventricular pressure overload, which results in right …

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary vascular disease
characterized by progressive pulmonary artery pressure elevation, increased pulmonary …

Macrophages are major players in the pathogenesis of pulmonary arterial hypertension
(PAH). To investigate whether lung macrophages and pulmonary-artery smooth muscle cells …

In pulmonary arterial hypertension (PAH), there is overexpression of the chemokine, CC
chemokine ligand type 2 (CCL2), and infiltration of myeloid cells into the pulmonary …

The recent discovery that sporadic and familial primary pulmonary hypertension can be
associated with germline mutations of genes encoding receptor members of the …

Rationale: Inflammatory cytokines may affect pulmonary vascular remodeling in idiopathic
pulmonary arterial hypertension (IPAH). CC chemokine ligand 2 (CCL2) is synthesized by …

Abstract According to the World Symposium Pulmonary Hypertension (WSPH) classification,
pulmonary hypertension (PH) is classified into five categories based on etiology. Among …

Macrophages are innate immune cells that are specialized in maintaining tissue
homeostasis, because they command a broad sensory arsenal to detect disturbances in …

Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …

This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …