The inability of neurones to regenerate in the adult mammalian central nervous system
(CNS) is thought to be primarily a consequence of the inhospitable nature of the …

It is well established that axonal regeneration in the adult CNS is largely unsuccessful.
Numerous axon‐inhibitory molecules are now known to be present in the injured CNS, and …

Chondroitin sulphate proteoglycans (CSPGs) are up-regulated in the central nervous system
after injury, specifically around the lesion site where the glial scar forms. This structure …

Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which
form after damage to the adult central nervous system and act as a barrier to regenerating …

Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan
(GAG) chains. There is enormous structural diversity among CSPGs due to variation in the …

Injury to the CNS results in the formation of the glial scar, a primarily astrocytic structure that
represents an obstacle to regrowing axons. Chondroitin sulfate proteoglycans (CSPG) are …

In addition to chemotrophic and contact guidance theories that explain how long projection
neurons weave intricate patterns of connectivity within developing or regenerating neuronal …

J. Neurochem.(2011) 119, 176–188. Abstract The formation of the glial scar following a
spinal cord injury presents a significant barrier to the regenerative process. It is primarily …

After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

Following a CNS lesion many glial cell types proliferate and/or migrate to the lesion site,
forming the glial scar. The majority of these cells express chondroitin sulphate proteoglycans …