Objective: Insulin resistance is closely associated with two disparate aspects of lipid storage:
the intracellular lipid content of skeletal muscle and the magnitude of central adipose beds …

An increase in muscle lipid content has been postulated to relate closely to the evolution of
insulin resistance. We aimed to test whether the multiple indexes of lipid supply within man …

Increases in intramyocellular long-chain fatty acyl-CoAs (LCACoA) have been implicated in
the pathogenesis of insulin resistance in skeletal muscle. To test this hypothesis, we …

Background Insulin resistance and hyperinsulinemia are features of obesity, non-insulin-
dependent diabetes mellitus, and other disorders. Skeletal muscle is a major site of insulin …

The purpose of this study was to test the hypothesis that weight loss results in a reduction in
intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle …

Skeletal muscle is the largest tissue responsible for the insulin-stimulated disposal of
glucose. However, identifying the link between excess body fat and impaired insulin …

A close relationship between elevated plasma free fatty acid (FFA) levels and insulin
resistance is commonly reported in obese subjects. The aim of the present study was to …

Context: Increased adipose tissue lipolytic activity is considered an important factor in the
pathogenesis of skeletal muscle insulin resistance associated with obesity. Objective: The …

Whether visceral adipose tissue has a uniquely powerful association with insulin resistance
or whether subcutaneous abdominal fat shares this link has generated controversy in the …

We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is
associated with insulin resistance and that this may be mediated by the oxidative capacity of …