Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16‐induced tumors

MCW Feltkamp, GR Vreugdenhil… - European journal of …, 1995 - Wiley Online Library
Previously, we have shown that immunization with human papillomavirus (HPV) type 16‐
derived cytotoxic T lymphocyte (CTL) epitope E7 49–57 (RAHYNIVTF) renders C57BL/6 …

Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

MCW Feltkamp, HL Smits… - European journal of …, 1993 - Wiley Online Library
Cytotoxic T lymphocyte (CTL) peptide epitopes can be used for immunization of mice
against lethal virus infection. To study whether this approach can be successful against virus …

Cytotoxic-T-lymphocyte human papillomavirus type 16 E5 peptide with CpG-oligodeoxynucleotide can eliminate tumor growth in C57BL/6 mice

YF Chen, CW Lin, YP Tsao, SL Chen - Journal of virology, 2004 - Am Soc Microbiol
Previously, we identified human papillomavirus type 16 (HPV-16) E5 as a tumor rejection
antigen that can induce cytotoxic T lymphocytes (CTLs) to protect against tumor growth (DW …

Specificity of human cytotoxic T lymphocytes induced by a human papillomavirus type 16 E7-derived peptide

I Jochmus, W Osen, A Altmann… - Journal of general …, 1997 - microbiologyresearch.org
In order to establish tumour-specific cytotoxic T lymphocyte (CTL) cell lines, T cells from a
human papillomavirus (HPV) type 16-positive patient with a cervical carcinoma in situ and …

Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides

S Zwaveling, SCF Mota, J Nouta… - The Journal of …, 2002 - journals.aai.org
Peptide-based vaccines aimed at the induction of effective T cell responses against
established cancers have so far only met with limited clinical success and clearly need to be …

Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16

I Melero, MC Singhal, P McGowan, HS Haugen… - Journal of …, 1997 - Am Soc Microbiol
Certain human papillomaviruses (HPV) have been implicated in the etiology of cervical
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …

Peptide vaccination with an anchor-replaced CTL epitope protects against human papillomavirus type 16-induced tumors expressing the wild-type epitope

MPM Vierboom, MCW Feltkamp, A Neisig… - Journal of …, 1998 - journals.lww.com
Anchor residues in cytotoxic T-lymphocyte (CTL) epitope-bearing peptides are buried deep
in the major histocompatibility complex (MHC) class I antigen-presenting groove and are …

Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice

P Ohlschlager, W Osen, K Dell, S Faath… - Journal of …, 2003 - Am Soc Microbiol
We analyzed capsomeres of human papillomavirus type 16 (HPV16) consisting of the L1
major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this …

Dendritic cells as carriers for a cytotoxic T-lymphocyte epitope–based peptide vaccine in protection against a human papillomavirus type 16–induced tumor

MA Ossevoort, MCW Feltkamp… - Journal of …, 1995 - journals.lww.com
Previously we have demonstrated that two doses of a cytotoxic T lymphocyte (CTL) epitope–
based peptide vaccine of human papillomavirus type 16 (HPV 16) E7 aa 49–57 elicit …

Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A* 0201-binding …

ME Ressing, A Sette, RM Brandt, J Ruppert… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
Abstract Human papillomavirus type 16 (HPV16) is strongly associated with cervical
carcinogenesis. The HPV16 E6 and E7 oncoproteins are constitutively expressed in the …