The cardiovascular safety of incretin-based therapies: a review of the evidence

JR Petrie - Cardiovascular Diabetology, 2013 - Springer
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in people with
diabetes and therefore managing cardiovascular (CV) risk is a critical component of …

Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin—based therapies

K Ban, S Hui, DJ Drucker, M Husain - Journal of the American Society of …, 2009 - Elsevier
Cardiovascular disease is the predominant cause of death in diabetic patients, and yet the
cardiovascular benefits of traditional drug treatments for hyperglycemia have been elusive …

Cardiovascular actions of incretin-based therapies

JR Ussher, DJ Drucker - Circulation research, 2014 - Am Heart Assoc
Glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4)
inhibitors represent 2 distinct classes of incretin-based therapies used for the treatment of …

Cardiovascular comorbidities of type 2 diabetes mellitus: defining the potential of glucagonlike peptide–1-based therapies

R Chilton, J Wyatt, S Nandish, R Oliveros… - The American journal of …, 2011 - Elsevier
The global epidemic of diabetes mellitus (∼ 95% type 2 diabetes) has been fueled by a
parallel increase in obesity and overweight. Together, these metabolic disease epidemics …

Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans

K Piotrowski, M Becker, J Zugwurst… - Cardiovascular …, 2013 - Springer
Background GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in
response to nutritional stimuli leading to pancreatic insulin secretion and suppression of …

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor–dependent and …

K Ban, MH Noyan-Ashraf, J Hoefer, SS Bolz… - Circulation, 2008 - Am Heart Assoc
Background—The glucagon-like peptide 1 receptor (GLP-1R) is believed to mediate
glucoregulatory and cardiovascular effects of the incretin hormone GLP-1 (7-36)(GLP-1) …

Diabetes and cardiovascular disease: the potential benefit of incretin-based therapies

D Addison, D Aguilar - Current atherosclerosis reports, 2011 - Springer
The health burden of type 2 diabetes mellitus continues to increase worldwide. A substantial
portion of this burden is due to the development of cardiovascular disease in patients with …

Selective targeting of glucagon‐like peptide‐1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes

M Tate, A Chong, E Robinson… - British journal of …, 2015 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone whose glucose‐dependent
insulinotropic actions have been harnessed as a novel therapy for glycaemic control in type …

Cardiovascular effects of glucagonlike peptide–1 agonists

MH Davidson - The American journal of cardiology, 2011 - Elsevier
Type 2 diabetes mellitus is acknowledged as a major risk factor for the development of
cardiovascular disease (CVD). Advancing treatment options for person with diabetes …

Beyond glycemic control: treating the entire type 2 diabetes disorder

S Brunton - Postgraduate medicine, 2009 - Taylor & Francis
The prevalence of type 2 diabetes mellitus, which is directly associated with
overweight/obesity and increased cardiovascular disease risk, is projected to continue to …