Is left ventricular noncompaction a trait, phenotype, or disease? The evidence points to phenotype

RE Hershberger, A Morales… - Circulation: Cardiovascular …, 2017 - Am Heart Assoc
2 Hershberger et al Left Ventricular Noncompaction 1480 individuals from the UK-Canadian
TASCFORCE study (Tayside Screening for Cardiac Events), also identified LVNC as a …

Genetic testing in pediatric left ventricular noncompaction

EM Miller, RB Hinton, R Czosek, A Lorts… - Circulation …, 2017 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) can occur in isolation or can co-occur
with a cardiomyopathy phenotype or cardiovascular malformation. The yield of …

Clinical and genetic complexities of left ventricular noncompaction: preventing overdiagnosis in a disease we do not understand

SB Ross, C Semsarian - JAMA cardiology, 2018 - jamanetwork.com
The Existing Evidence Traditionally, LVNC has been diagnosed according to criteria applied
to transthoracic echocardiogram results, which focus on the ratio of noncompacted to …

Genetic architecture of left ventricular noncompaction in adults

SB Ross, ES Singer, E Driscoll, N Nowak… - Human genome …, 2020 - nature.com
The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …

Navigating genetic and phenotypic uncertainty in left ventricular noncompaction

JW Rhee, ME Grove, EA Ashley - Circulation: Cardiovascular …, 2017 - Am Heart Assoc
Presently, although controversial, LVNC is considered to be primarily a genetic condition. It
frequently manifests as a monogenic disease, exhibiting various forms of inheritance with …

[HTML][HTML] Left ventricular noncompaction: phenotype in an integrated model of cardiomyopathy?

E Oechslin, S Klaassen - Journal of the American College of Cardiology, 2019 - jacc.org
scribes a myocardial phenotype resulting from different, incompletely understood, and
undefined genetic and pathophysiological mechanisms (1). In a recent retrospective Dutch …

Genetic spectrum of left ventricular non-compaction in paediatric patients

T Vershinina, Y Fomicheva, A Muravyev, J Jorholt… - Cardiology, 2020 - karger.com
Introduction: Left ventricular non-compaction (LVNC) represents a genetically
heterogeneous cardiomyopathy which occurs in both children and adults. Its genetic …

Genetic basis of left ventricular noncompaction

P Rojanasopondist, L Nesheiwat… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Left ventricular noncompaction (LVNC) is the third most common pediatric
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …

[HTML][HTML] Left ventricular noncompaction: from physiologic remodeling to noncompaction cardiomyopathy

E Oechslin, R Jenni - Journal of the American College of Cardiology, 2018 - jacc.org
noncompaction cardiomyopathy (NCCM) has reached popularity like that of a Hollywood
star and has been promoted to one of “Topic of Fame” in the current publications, along with …

Left ventricular noncompaction—a systematic review of risk factors in the pediatric population

K Łuczak-Woźniak, B Werner - Journal of Clinical Medicine, 2021 - mdpi.com
Left ventricular noncompaction (LVNC) is a heterogeneous, often hereditary group of
diseases, which may have diverse clinical manifestations. This article reviews the risk factors …