Is left ventricular noncompaction a trait, phenotype, or disease? The evidence points to phenotype
RE Hershberger, A Morales… - Circulation: Cardiovascular …, 2017 - Am Heart Assoc
2 Hershberger et al Left Ventricular Noncompaction 1480 individuals from the UK-Canadian
TASCFORCE study (Tayside Screening for Cardiac Events), also identified LVNC as a …
TASCFORCE study (Tayside Screening for Cardiac Events), also identified LVNC as a …
Genetic testing in pediatric left ventricular noncompaction
EM Miller, RB Hinton, R Czosek, A Lorts… - Circulation …, 2017 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) can occur in isolation or can co-occur
with a cardiomyopathy phenotype or cardiovascular malformation. The yield of …
with a cardiomyopathy phenotype or cardiovascular malformation. The yield of …
Clinical and genetic complexities of left ventricular noncompaction: preventing overdiagnosis in a disease we do not understand
SB Ross, C Semsarian - JAMA cardiology, 2018 - jamanetwork.com
The Existing Evidence Traditionally, LVNC has been diagnosed according to criteria applied
to transthoracic echocardiogram results, which focus on the ratio of noncompacted to …
to transthoracic echocardiogram results, which focus on the ratio of noncompacted to …
Genetic architecture of left ventricular noncompaction in adults
SB Ross, ES Singer, E Driscoll, N Nowak… - Human genome …, 2020 - nature.com
The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …
Navigating genetic and phenotypic uncertainty in left ventricular noncompaction
Presently, although controversial, LVNC is considered to be primarily a genetic condition. It
frequently manifests as a monogenic disease, exhibiting various forms of inheritance with …
frequently manifests as a monogenic disease, exhibiting various forms of inheritance with …
[HTML][HTML] Left ventricular noncompaction: phenotype in an integrated model of cardiomyopathy?
E Oechslin, S Klaassen - Journal of the American College of Cardiology, 2019 - jacc.org
scribes a myocardial phenotype resulting from different, incompletely understood, and
undefined genetic and pathophysiological mechanisms (1). In a recent retrospective Dutch …
undefined genetic and pathophysiological mechanisms (1). In a recent retrospective Dutch …
Genetic spectrum of left ventricular non-compaction in paediatric patients
T Vershinina, Y Fomicheva, A Muravyev, J Jorholt… - Cardiology, 2020 - karger.com
Introduction: Left ventricular non-compaction (LVNC) represents a genetically
heterogeneous cardiomyopathy which occurs in both children and adults. Its genetic …
heterogeneous cardiomyopathy which occurs in both children and adults. Its genetic …
Genetic basis of left ventricular noncompaction
P Rojanasopondist, L Nesheiwat… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Left ventricular noncompaction (LVNC) is the third most common pediatric
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …
[HTML][HTML] Left ventricular noncompaction: from physiologic remodeling to noncompaction cardiomyopathy
E Oechslin, R Jenni - Journal of the American College of Cardiology, 2018 - jacc.org
noncompaction cardiomyopathy (NCCM) has reached popularity like that of a Hollywood
star and has been promoted to one of “Topic of Fame” in the current publications, along with …
star and has been promoted to one of “Topic of Fame” in the current publications, along with …
Left ventricular noncompaction—a systematic review of risk factors in the pediatric population
K Łuczak-Woźniak, B Werner - Journal of Clinical Medicine, 2021 - mdpi.com
Left ventricular noncompaction (LVNC) is a heterogeneous, often hereditary group of
diseases, which may have diverse clinical manifestations. This article reviews the risk factors …
diseases, which may have diverse clinical manifestations. This article reviews the risk factors …