Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the predominant
form of dementia. Since its initial description by Alois Alzheimer in 1906, several advances …

In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …

Alzheimer's disease (AD) and vascular dementia are the major causes of cognitive disorders
worldwide. They are characterized by cognitive impairments along with neuropsychiatric …

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …

Astrocytes, which are five-fold more numerous than neurons in the central nervous system
(CNS), are traditionally viewed to provide simple structural and nutritional supports for …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

In recent years, glial cells have been acknowledged as key players in the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative condition in which an accumulation of …