Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease

MD Sweeney, AP Sagare… - Journal of Cerebral …, 2015 - journals.sagepub.com
Alzheimer's disease (AD) is the most common form of age-related dementias. In addition to
genetics, environment, and lifestyle, growing evidence supports vascular contributions to …

Vascular dysfunction in Alzheimer's disease: a prelude to the pathological process or a consequence of it?

K Govindpani, LG McNamara, NR Smith… - Journal of clinical …, 2019 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Murine beta-amyloid (1–42) oligomers disrupt endothelial barrier integrity and VEGFR signaling via activating astrocytes to release deleterious soluble factors

Q Yue, X Zhou, Z Zhang, MPM Hoi - International Journal of Molecular …, 2022 - mdpi.com
Transgenic mouse models of Alzheimer's disease (AD) overexpress mutations of the human
amyloid protein precursor (APP) and presenilin-1 (PSEN1) genes, which are known causes …

Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress

RA Quintanilla, JA Orellana, R von Bernhardi - Archives of Medical …, 2012 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
dementia and the presence of amyloid plaques and anomalous tau aggregates. Although …

[PDF][PDF] Vascular and nonvascular mechanisms of cognitive impairment and dementia

B Kara, MN Gordon, M Gifani, AM Dorrance… - Clinics in geriatric …, 2023 - Elsevier
Aging, familial gene mutations, and genetic, environmental, and modifiable lifestyle risk
factors predispose individuals to cognitive impairment or dementia by influencing the …

The Vascular-immune hypothesis of Alzheimer's disease

RI Mehta, RI Mehta - Biomedicines, 2023 - mdpi.com
Alzheimer's disease (AD) is a devastating and irreversible neurodegenerative disorder with
unknown etiology. While its cause is unclear, a number of theories have been proposed to …

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

S Takeda, N Sato, R Morishita - Frontiers in aging neuroscience, 2014 - frontiersin.org
The incidence of dementia is increasing at an alarming rate, and has become a major public
health concern. Alzheimer disease (AD) is the most common form of dementia and is …

Common signaling pathways involved in Alzheimer's disease and stroke: Two Faces of the Same Coin

TK Das, BP Ganesh… - Journal of Alzheimer's …, 2023 - content.iospress.com
Alzheimer's disease (AD) and stroke are two interrelated neurodegenerative disorders
which are the leading cause of death and affect the neurons in the brain and central nervous …

Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?

ZZ Chong, F Li, K Maiese - Current neurovascular research, 2005 - ingentaconnect.com
Alzheimer's disease is a progressive disorder that results in the loss of cognitive function
and memory. Although traditionally defined by the presence of extracellular plaques of …

Contribution of cerebral microvascular mechanisms to age-related cognitive impairment and dementia

X Fang, RF Crumpler, KN Thomas… - Physiology …, 2022 - akjournals.com
Cognitive impairment and dementia are significant health burdens worldwide. Aging,
hypertension, and diabetes are the primary risk factors for Alzheimer's disease and …