Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human
pathologies. The pathway is executed by a core machinery comprising the RIPK1 and …

Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death
which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase …

Necroptosis, initially identified as a backup cell death program when apoptosis is hindered,
is a prominent feature in the etiology and progression of many human diseases, such as …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

The necroptosis cell death pathway has been implicated in host defense and in the
pathology of inflammatory diseases. While phosphorylation of the necroptotic effector …

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

Necroptosis is a caspase-independent modality of cell death implicated in many
inflammatory pathologies. The execution of this pathway requires the formation of a cytosolic …

The past decade has seen the emergence of the necroptosis programmed cell death
pathway as an important contributor to the pathophysiology of myriad diseases. The receptor …