BCL-XL, an anti-apoptotic BCL-2 family protein, plays a key role in cancer cell survival.
However, the potential of BCL-XL as an anti-cancer target has been hampered by the on …

Anti-apoptotic protein BCL-X L plays a key role in tumorigenesis and cancer chemotherapy
resistance, rendering it an attractive target for cancer treatment. However, BCL-X L inhibitors …

BCL-XL and BCL-2 are important targets for cancer treatment. BCL-XL specific proteolysis-
targeting chimeras (PROTACs) have been developed to circumvent the on-target platelet …

Apoptosis is a highly regulated cellular process. Aberration in apoptosis is a common
characteristic of various disorders. Therefore, proteins involved in apoptosis are prime …

Abstract Targeting BCL-X L via PROTACs is a promising strategy in reducing BCL-X L
inhibition associated platelet toxicity. Recently, we reported potent BCL-X L PROTAC …

Abstract BCL-X L is an anti-apoptotic protein that plays an important role in tumorigenesis,
metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-X L …

The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival.
Structural studies of Bcl-xL formed the foundation for the development of the first Bcl-2 family …

Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic
process. This family comprises proapoptotic and prosurvival proteins, and shifting the …

Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of
human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL represents a promising …

The induction of apoptosis in tumor cells represents a promising approach to the treatment
of cancer. Accordingly, compounds that interact with the Bcl-2 family of proteins, which are …