Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application

X Yuan, H Bu, J Zhou, CY Yang… - Journal of medicinal …, 2020 - ACS Publications
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …

[HTML][HTML] Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

Z Song, M Wang, Y Ge, XP Chen, Z Xu, Y Sun… - … Pharmaceutica Sinica B, 2021 - Elsevier
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …

[HTML][HTML] Strategies to overcome drug resistance using SHP2 inhibitors

M Liu, S Gao, RM Elhassan, X Hou, H Fang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …

Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment

DL Kerr, F Haderk, TG Bivona - Current opinion in chemical biology, 2021 - Elsevier
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …

A comprehensive review of SHP2 and its role in cancer

MD Asmamaw, XJ Shi, LR Zhang, HM Liu - Cellular Oncology, 2022 - Springer
Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor

J Garcia Fortanet, CHT Chen, YNP Chen… - Journal of medicinal …, 2016 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also …

Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment

J Xie, X Si, S Gu, M Wang, J Shen, H Li… - Journal of medicinal …, 2017 - ACS Publications
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is
involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways …

Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials

Y Song, M Zhao, H Zhang, B Yu - Pharmacology & therapeutics, 2022 - Elsevier
Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

Functions of Shp2 in cancer

J Zhang, F Zhang, R Niu - Journal of cellular and molecular …, 2015 - Wiley Online Library
Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …

Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer

MJ LaMarche, M Acker, A Argintaru… - Journal of medicinal …, 2020 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays …