Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies

TE Golde - Journal of neurochemistry, 2016 - Wiley Online Library
It has now been~ 30 years since the Alzheimer's disease (AD) research entered what may
be termed the 'molecular era'that began with the identification of the amyloid β protein (Aβ) …

Current perspectives on pharmacotherapy of Alzheimer's disease

K Chopra, S Misra, A Kuhad - Expert opinion on pharmacotherapy, 2011 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a daunting public health threat that has prompted
the scientific community's ongoing efforts to decipher the underlying disease mechanism …

[HTML][HTML] Novel targets for Alzheimer's disease treatment

JD Grill, JL Cummings - Expert review of neurotherapeutics, 2010 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disease for which no cure
exists. There is substantial need for new therapies that offer improved symptomatic benefit …

Targeting Aβ and tau in Alzheimer's disease, an early interim report

TE Golde, L Petrucelli, J Lewis - Experimental neurology, 2010 - Elsevier
The amyloid β (Aβ) and tau proteins, which misfold, aggregate, and accumulate in the
Alzheimer's disease (AD) brain, are implicated as central factors in a complex …

Alzheimer's disease: strategies for disease modification

M Citron - Nature reviews Drug discovery, 2010 - nature.com
Alzheimer's disease is the largest unmet medical need in neurology. Current drugs improve
symptoms, but do not have profound disease-modifying effects. However, in recent years …

Current therapeutic targets for the treatment of Alzheimer's disease

JD Grill, JL Cummings - Expert review of neurotherapeutics, 2010 - Taylor & Francis
Alzheimer's disease is a progressive neurodegenerative disease for which no cure exists.
There is a substantial need for new therapies that offer improved symptomatic benefit and …

Should drug discovery scientists still embrace the amyloid hypothesis for Alzheimer's disease or should they be looking elsewhere?

BP Imbimbo, S Ippati, M Watling - Expert Opinion on Drug …, 2020 - Taylor & Francis
ABSTRACT Introduction Alzheimer's Disease (AD) represents a large and growing
challenge to patients, carers and healthcare systems, yet extensive efforts to develop …

Alzheimer's Disease: Development of Disease-Modifying Treatments Is the Challenge for Our Generation

CW Lindsley - ACS chemical neuroscience, 2012 - ACS Publications
Medicinal Chemistry Letters to highlight advances in the pharmacology, medicinal
chemistry, and therapeutic strategies currently under development for Alzheimer's disease …

Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease

Y Madav, S Wairkar, B Prabhakar - Brain research bulletin, 2019 - Elsevier
Alzheimer's disease (AD) has been a global concern for years due to its severe implications
that affects the quality of life of the patients. The available line of therapy for treating …

Therapeutic opportunities in Alzheimer disease: one for all or all for one?

MW Marlatt, KM Webber, PI Moreira… - Current medicinal …, 2005 - ingentaconnect.com
In recent years, Alzheimer disease (AD) has received great attention as an incurable and
fatal disease that threatens the lives of aging individuals. Debates regarding areas of …