IL-25 regulates Th17 function in autoimmune inflammation
MA Kleinschek, AM Owyang, B Joyce-Shaikh… - The Journal of …, 2007 - rupress.org
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
C Sutton, C Brereton, B Keogh, KHG Mills… - The Journal of …, 2006 - rupress.org
It was recently demonstrated that interleukin (IL)-23–driven IL-17–producing (ThIL-17) T
cells mediate inflammatory pathology in certain autoimmune diseases. We show that the …
cells mediate inflammatory pathology in certain autoimmune diseases. We show that the …
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
CL Langrish, Y Chen, WM Blumenschein… - The Journal of …, 2005 - rupress.org
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper …
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper …
[HTML][HTML] Anti–IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
Y Chen, CL Langrish, B Mckenzie… - The Journal of …, 2006 - Am Soc Clin Investig
IL-23 is a member of the IL-12 cytokine family that drives a highly pathogenic T cell
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
K Kreymborg, R Etzensperger, L Dumoutier… - The Journal of …, 2007 - journals.aai.org
Abstract Lately, IL-17-secreting Th cells have received an overwhelming amount of attention
and are now widely held to be the major pathogenic population in autoimmune diseases. In …
and are now widely held to be the major pathogenic population in autoimmune diseases. In …
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
JS Stumhofer, A Laurence, EH Wilson, E Huang… - Nature …, 2006 - nature.com
Studies have focused on the events that influence the development of interleukin 17 (IL-17)–
producing T helper cells (TH-17 cells) associated with autoimmunity, such as experimental …
producing T helper cells (TH-17 cells) associated with autoimmunity, such as experimental …
[HTML][HTML] Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
S Aggarwal, N Ghilardi, MH Xie, FJ de Sauvage… - Journal of Biological …, 2003 - ASBMB
Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells.
Despite increasing evidence that high levels of IL-17 are associated with several chronic …
Despite increasing evidence that high levels of IL-17 are associated with several chronic …
[PDF][PDF] Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1β-producing myeloid cells that promote pathogenic T cells
AM McGinley, CE Sutton, SC Edwards, CM Leane… - Immunity, 2020 - cell.com
Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
DC Newcomb, W Zhou, ML Moore… - The Journal of …, 2009 - journals.aai.org
IL-17A is produced from Th17 cells, and is involved in many autoimmune and inflammatory
diseases. IL-13R has not previously been reported to be functionally expressed on T cells; …
diseases. IL-13R has not previously been reported to be functionally expressed on T cells; …
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
IL-17 is a proinflammatory cytokine that activates T cells and other immune cells to produce
a variety of cytokines, chemokines, and cell adhesion molecules. This cytokine is …
a variety of cytokines, chemokines, and cell adhesion molecules. This cytokine is …