IL-23 plays a critical role establishing inflammatory immunity and enhancing IL-17
production in vivo. However, an understanding of how it performs those functions has been …

Abstract Interleukin (IL)-17 (also known as IL-17A), the signature cytokine of the newly
described T helper 17 (Th17) cell population, has been implicated in the pathogenesis of …

Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …

The interleukin‐17 (IL‐17) family consists of six cytokines in mammals. Among them, IL‐17
and IL‐17F are expressed by a novel subset of CD4+ helper T cells and play critical function …

T‐helper 17 (Th17) cells are a newly discovered CD4+ helper T‐cell subset that produces
interleukin‐17A (IL‐17A) and IL‐17F. IL‐17A plays important roles in allergic responses …

ABSTRACT Interleukin-12 (IL-12) has long been considered essential in T-cell-mediated
autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental …

Th17 cells are a subset of T helper cells that have been recently found to play important
functions in host defense and the pathogenesis of various human autoimmune and …

The discovery of a new lineage of helper T cells that selectively produces interleukin (IL)-17
has provided exciting new insights into immunoregulation, host defense and the …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-
23 to become encephalitogenic, but the mechanism by which IL-23 promotes their …

Summary Although several interleukin-17 (IL-17) family members and their receptors have
been recently appreciated as important regulators in inflammatory diseases, the function of …