IL-23–produced by dendritic cells–and Th17 cells have both been identified as major factors
involved in autoimmune inflammation, yet their relationship with each other remains …

IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation
and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the …

Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including
organ-specific autoimmune diseases in mice and humans. Despite the broadly documented …

IL-27 is a recently defined family member of the long-chain, four-helix bundle cytokines,
which consist of EBI3, an IL-12p40-related protein, and p28, an IL-12p35-related …

Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of
interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family …

Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which
has an expression pattern regulated similarly to IL-17, is poorly understood. We show that …

Interferon (IFN)-β is a commonly used therapy for relapsing remitting multiple sclerosis
(RRMS). However its protective mechanism is still unclear and the failure of many patients to …

Th17 cells contribute to mucosal immunity by stimulating epithelial cells to induce
antimicrobial peptides, granulopoiesis, neutrophil recruitment, and tissue repair. Recent …

Abstract IL‐17 and IL‐22 are typical cytokines produced by the Th17 T cell subset, but it is
unclear if Th17 cytokines can be produced by other cell types. We demonstrate that IL‐10 …

IL-17 is a T cell-derived cytokine that may play an important role in the initiation or
maintenance of the proinflammatory response. Whereas expression of IL-17 is restricted to …