Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development
P Gibson, JH Gill, PA Khan, JM Seargent… - Molecular cancer …, 2003 - AACR
The cytochrome P450 family of enzymes is involved in the Phase I metabolism of a wide
variety of compounds. Although generally involved with detoxification, overexpression of …
variety of compounds. Although generally involved with detoxification, overexpression of …
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors
Cytochrome P450 (CYP) 2J2 is one of the human CYPs involved in phase I xenobiotics
metabolism. It is mainly expressed in extrahepatic tissues, including intestine and …
metabolism. It is mainly expressed in extrahepatic tissues, including intestine and …
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
H Wang, LM Tompkins - Current drug metabolism, 2008 - ingentaconnect.com
Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …
Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?
The cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of procarcinogens and
xenobiotics. Human CYP1B1 protein has been detected in a variety of tumors but is not …
xenobiotics. Human CYP1B1 protein has been detected in a variety of tumors but is not …
Cytochrome P450 1B1: a novel anticancer therapeutic target
MCE McFadyen, GI Murray - Future oncology, 2005 - Taylor & Francis
Cytochrome P450 (CYP) 1B1 is overexpressed in tumor cells and is also recognized as a
biomarker of the tumor phenotype. This review highlights the tremendous potential of this …
biomarker of the tumor phenotype. This review highlights the tremendous potential of this …
[HTML][HTML] Evidence-based capacity of natural cytochrome enzyme inhibitors to increase the effectivity of antineoplastic drugs
L Manthalkar, Ajazuddin, S Bhattacharya - Discover Oncology, 2022 - Springer
Cytochrome (CYP) enzymes catalyze the metabolism of numerous exogenous and
endogenous substrates in cancer therapy leading to significant drug interactions due to their …
endogenous substrates in cancer therapy leading to significant drug interactions due to their …
Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1
PH Roos, HM Bolt - Expert opinion on drug metabolism & …, 2005 - Taylor & Francis
Molecular epidemiological studies are now a powerful tool to determine differential genetic
susceptibilities to cancer-causing agents, and to obtain information on potential …
susceptibilities to cancer-causing agents, and to obtain information on potential …
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development
SF Zhou, ZW Zhou, LP Yang… - Current medicinal …, 2009 - ingentaconnect.com
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …
[PDF][PDF] Screening of potential anticancer compounds from marketed drugs: aripiprazole, haloperidol, miconazole, and terfenadine inhibit cytochrome P450 2J2
KH Liu - Journal of Life Science, 2011 - Citeseer
Cytochrome P450 2J2 (CYP2J2) plays important roles in the metabolism of endogenous
metabolites such as arachidonic acid as well as therapeutic drugs. CYP2J2 is …
metabolites such as arachidonic acid as well as therapeutic drugs. CYP2J2 is …
Metabolism and mechanism of human cytochrome P450 enzyme 1A2
Human cytochrome P450 enzyme 1A2 (CYP1A2) is one of the most important cytochrome
P450 (CYP) enzymes in the liver, accounting for 13% to 15% of hepatic CYP enzymes …
P450 (CYP) enzymes in the liver, accounting for 13% to 15% of hepatic CYP enzymes …