CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …

Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …

Extrahepatic cytochrome P450 enzymes (CYP450) are pivotal in the metabolism of
endogenous substrates and xenobiotics. CYP2J2 is a major cardiac CYP450 and primarily …

Genetic polymorphisms in CYP2C8 can influence the metabolism of important therapeutic
agents and cause interindividual variation in drug response and toxicity. The significance of …

Introduction: CYP, a ubiquitous superfamily of enzymes expressed in major organs in
humans, plays a key role in biosynthesis of steroids and metabolism of xenobiotics …

Cytochrome P450 1A1 (CYP1A1) is a hepatic and extrahepatic enzyme that is regulated by
the aryl hydrocarbon receptor signaling pathway. With the growing human exposure to …

The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …

One consequence of the devotion of this journal to drug metabolism and the mechanisms by
which drugs interact with each other is that cytochrome P450 enzymes (CYPs) will figure …

Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in
precarcinogen metabolism; for this reason it is relevant to know more in depth the …

The active site topology, substrate specificity, and biological roles of the human cytochrome
P450 CYP2J2, which is mainly expressed in the cardiovascular system, are poorly known …