Objective: To establish the generality of cerebrovascular pathology frequently observed with
Alzheimer disease, we have assessed blood–brain barrier (BBB) integrity using the …

Background Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to
pathogenesis and pathology of vascular-based neurodegenerative disorders such as …

Harmful materials in the blood are prevented from entering the healthy brain by a highly
selective blood–brain barrier (BBB), and impairment of barrier function has been associated …

Cerebral “microvascular” disease occurs in lacunar stroke, leukoaraiosis, vascular dementia
and Alzheimer's disease. It may arise from or contribute to insidious damage to the blood …

Blood-brain barrier (BBB) regulates transport of various molecules and maintains brain
homeostasis. Perturbed intracellular Ca2+ homeostasis and BBB damage have been …

Thinning and discontinuities within the vascular basement membrane (VBM) are associated
with leakage of the plasma protein prothrombin across the blood–brain barrier (BBB) in …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Combined evidence from neuroimaging and neuropathological studies shows that signs of
vascular pathology and brain hypoperfusion develop early in Alzheimer's disease (AD). To …

Background and Purpose—Age-related changes in the cerebrovasculature, including blood–
brain barrier (BBB) disruption, are emerging as potential risks for diverse neurological …

Blood-brain barrier (BBB) dysfunction might be an important component of many
neurodegenerative disorders. In this study, we investigated its role in dementia using large …