Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1, 3, 4-oxadiazole scaffold as FabH inhibitors
Y Li, Y Luo, Y Hu, DD Zhu, S Zhang, ZJ Liu… - Bioorganic & medicinal …, 2012 - Elsevier
Nitroimidazoles and their derivatives have drawn continuing interest over the years because
of their varied biological activities, recently found application in drug development for …
of their varied biological activities, recently found application in drug development for …
Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors
YT Duan, ZC Wang, YL Sang, XX Tao… - European Journal of …, 2014 - Elsevier
Abstract A series of 2-Styryl-5-Nitroimidazole derivatives (25–48) have been synthesized
and their biological activities were also evaluated against two Gram-negative bacterial …
and their biological activities were also evaluated against two Gram-negative bacterial …
Design, synthesis and molecular docking of 1, 4-benzodioxane thiazolidinedione piperazine derivatives as FabH inhibitors
J Sun, W He, HY Liu, J Qin, CL Ye - Bioorganic Chemistry, 2019 - Elsevier
Abstract A series of novel 1, 4-benzodioxane thiazolidinedione piperazine derivatives
targeting FabH were designed and synthesized. The compounds exhibited better inhibitory …
targeting FabH were designed and synthesized. The compounds exhibited better inhibitory …
Synthesis and Antimicrobial Activities of Oximes Derived from O‐Benzylhydroxylamine as FabH Inhibitors
Y Luo, LR Zhang, Y Hu, S Zhang, J Fu… - …, 2012 - Wiley Online Library
Forty‐three oxime derivatives were synthesized by allowing O‐benzylhydroxylamines to
react with primary benzaldehydes or salicylaldehydes; these products were gauged as …
react with primary benzaldehydes or salicylaldehydes; these products were gauged as …
Discovery of novel bacterial FabH inhibitors (Pyrazol-Benzimidazole amide derivatives): Design, synthesis, bioassay, molecular docking and crystal structure …
YT Wang, TQ Shi, J Fu, HL Zhu - European journal of medicinal chemistry, 2019 - Elsevier
The enzyme FabH catalyzes the initial step of fatty acid biosynthesis that is essential for
bacterial survival. Therefore, FabH has been identified as an attractive target for the …
bacterial survival. Therefore, FabH has been identified as an attractive target for the …
Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1, 2, 4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory
F Zhang, Q Wen, SF Wang, BS Karim, YS Yang… - Bioorganic & Medicinal …, 2014 - Elsevier
A series of novel schiff base derivatives (H 1–H 20) containing pyrazine and triazole moiety
have been designed and synthesized, and their biological activities were also evaluated as …
have been designed and synthesized, and their biological activities were also evaluated as …
Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity
JR Li, DD Li, RR Wang, J Sun, JJ Dong, QR Du… - European journal of …, 2014 - Elsevier
Components of fatty acid biosynthetic pathway have been identified as attractive targets for
the development of new antibacterial agents. Compounds of series A (4a–4g) and series B …
the development of new antibacterial agents. Compounds of series A (4a–4g) and series B …
Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors
Y Li, CP Zhao, HP Ma, MY Zhao, YR Xue… - Bioorganic & medicinal …, 2013 - Elsevier
FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is critically important to the initiation
of fatty acid biosynthesis and is highly conserved among Gram-positive and Gram-negative …
of fatty acid biosynthesis and is highly conserved among Gram-positive and Gram-negative …
Tailor made biheterocyclic pyrazoline-thiazolidinones as effective inhibitors of Escherichia coli FabH: Design, synthesis and structural studies
In the present study, a new series of biheterocycles pyrazoline-thiazolidinones derivatized at
fifth position with substituted arylidene groups were developed as potent inhibitors of …
fifth position with substituted arylidene groups were developed as potent inhibitors of …
Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
XL Wang, YB Zhang, JF Tang, YS Yang… - European journal of …, 2012 - Elsevier
Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation …
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