[HTML][HTML] Genetic factors and manganese-induced neurotoxicity
Manganese (Mn), is a trace metal required for normal physiological processes in humans.
Mn levels are tightly regulated, as high levels of Mn result in accumulation in the brain and …
Mn levels are tightly regulated, as high levels of Mn result in accumulation in the brain and …
[HTML][HTML] New insights on the role of manganese in Alzheimer's disease and Parkinson's disease
Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …
is necessary as a cofactor for many enzymes and is important in several physiological …
Manganese transport via the transferrin mechanism
TE Gunter, B Gerstner, KK Gunter, J Malecki, R Gelein… - Neurotoxicology, 2013 - Elsevier
Excessive manganese (Mn) uptake by brain cells, particularly in regions like the basal
ganglia, can lead to toxicity. Mn2+ is transported into cells via a number of mechanisms …
ganglia, can lead to toxicity. Mn2+ is transported into cells via a number of mechanisms …
Manganese in the diet: bioaccessibility, adequate intake, and neurotoxicological effects
AC Martins, BN Krum, L Queirós… - Journal of agricultural …, 2020 - ACS Publications
Manganese (Mn) is an essential element that participates in several biological processes.
Mn serves as a cofactor for several enzymes, such as glutamine synthetase and …
Mn serves as a cofactor for several enzymes, such as glutamine synthetase and …
Manganese (Mn) and iron (Fe): interdependency of transport and regulation
VA Fitsanakis, N Zhang, S Garcia, M Aschner - Neurotoxicity research, 2010 - Springer
Abstract Manganese (Mn) and iron (Fe) are transition metals that are crucial to the
appropriate growth, development, function, and maintenance of biological organisms …
appropriate growth, development, function, and maintenance of biological organisms …
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
GD Stanwood, DB Leitch, V Savchenko… - Journal of …, 2009 - Wiley Online Library
Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins
and lipids. Excessive environmental exposure to manganese can produce extrapyramidal …
and lipids. Excessive environmental exposure to manganese can produce extrapyramidal …
Manganese-induced neurotoxicity: from C. elegans to humans
Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal
cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn …
cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn …
The role of manganese dysregulation in neurological disease: emerging evidence
D Budinger, S Barral, AKS Soo, MA Kurian - The Lancet Neurology, 2021 - thelancet.com
Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …
spectrum of neurological disorders reflects its importance in brain development and key …
Manganese: recent advances in understanding its transport and neurotoxicity
The present review is based on presentations from the meeting of the Society of Toxicology
in San Diego, CA (March 2006). It addresses recent developments in the understanding of …
in San Diego, CA (March 2006). It addresses recent developments in the understanding of …
Manganese action in brain function
A Takeda - Brain Research Reviews, 2003 - Elsevier
Manganese, an essential trace metal, is supplied to the brain via both the blood–brain and
the blood–cerebrospinal fluid barriers. There are some mechanisms in this process and …
the blood–cerebrospinal fluid barriers. There are some mechanisms in this process and …