The central nervous system, and the basal ganglia in particular, is an important target in
manganese neurotoxicity, a disorder producing neurological symptoms similar to that of …

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Metals are ubiquitous chemical entities involved in a myriad of biological processes. Despite
their integral role in sustaining life, overexposure can lead to deleterious neurological …

Manganese represents an essential trace element that is accumulated and utilized by
virtually all forms of life. This redox active metal is a key cofactor for a wide range of …

Manganese intake can vary greatly with food choices, water composition, and supplement
use. Thus, individuals consuming Western diets consume from< 1 to> 10 mg Mn/d. The …

J. Neurochem.(2010) 112, 1190–1198. Abstract Although manganese (Mn) is an essential
trace element for human development and growth, chronic exposure to excessive Mn levels …

Manganese (Mn) neurotoxicity in adults can result in psychological and neurological
disturbances similar to Parkinson's disease, including extrapyramidal motor system defects …

The essential metal manganese becomes neurotoxic at elevated levels. Yet, the
mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of …

Neurotoxicity due to excessive brain manganese (Mn) accumulation can occur via
occupational exposure to aerosols or dusts that contain extremely high levels (> 1 …

Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …