Stress causes extensive changes in hippocampal genomic expression, leading to changes
in hippocampal structure and function. The dynamic changes in hippocampal gene …

Objective This study systematically investigated the effect of chronic stress on the
hippocampus and its damage mechanism at the whole genome level. Methods The rat …

Depression is a state of low mood and aversion to activity, affecting a person's thoughts,
behavior, motivation, feelings and sense of well-being, which is associated with dramatical …

Background BALB/cJ is a strain susceptible to stress and extremely susceptible to a
defective hedonic impact in response to chronic stressors. The strain offers much promise as …

There is increasing evidence that mood disorders may derive from the impact of
environmental pressure on genetically susceptible individuals. Stress-induced hippocampal …

Individual susceptibility determines the magnitude of stress effects on cognitive function. The
hippocampus, a brain region of memory consolidation, is vulnerable to stressful …

Stress refers to physiological or psychological stimuli that disrupt homeostasis and induce
pathophysiological conditions due to maladaptive response, sometimes resulting in mental …

Psychogenic stress contributes to the formation of brain pathology. Using gene expression
microarrays, we analyzed the hippocampal transcriptome of mice subjected to acute and …

Objective: Acute stress provides many beneficial effects whereas chronic stress contributes
to a variety of human health issues including anxiety, depression, gastrointestinal problems …

Stress arises from an external demand placed on an organism that triggers physiological,
cognitive and behavioural responses in order to cope with that request. It is thus an adaptive …