Many patients with type 2 diabetes have hyperglycemia as a result of deficiencies in both
insulin secretion and insulin action, that is, β-cell dysfunction and insulin resistance. Insulin …

Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

The syndromes of insulin resistance are a group of clinically diverse disorders, and our
understanding of their molecular pathogenesis has advanced in parallel with our …

Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and
energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the …

The humoral side of insulin resistance | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

This review postulates and presents recent evidence that insulin resistance is initiated in the
adipose tissue and also suggests that the adipose tissue may play a pivotal role in the …

The prevalence of obesity is a major cause of many chronic metabolic disorders, including
type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and cancer. Insulin …

A generally accepted view posits that insulin resistant condition in type 2 diabetes is caused
by defects at one or several levels of the insulin-signaling cascade in skeletal muscles …

Since the discovery of the tyrosine kinase activity of the insulin receptor (IR), researchers
have been engaged in intensive efforts to resolve physiological functions of IR and its major …

Insulin (INS) resistance use is an integral component of the cardiometabolic syndrome,
which often progresses to type 2 diabetes and cardiovascular disease (CVD) events …