Tissue-specific knockout of the IR gene in the pancreatic β cell has also been achieved by
breeding the same mice used to generate the MIRKO with transgenic mice expressing the …

Abstract Worldwide, more than 1.9 billion adults are overweight, and around 600 million
people suffer from obesity. Similarly,~ 382 million individuals live with diabetes, and 40 …

The metabolic syndrome affects more than a third of the US population, predisposing to the
development of type 2 diabetes and cardiovascular disease. The 2009 consensus statement …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

Human survival has relied upon the ability to withstand starvation through energy storage,
the capacity to fight off infection by a proinflammatory immune response, and the ability to …

Insulin signaling at target tissues is essential for growth and development and for normal
homeostasis of glucose, fat, and protein metabolism. Control over this process is therefore …

Insulin resistance is defined as a clinical state in which a normal or elevated insulin level
produces an attenuated biologic response. Specifically, the biologic response most studied …

Sedentary life style and high calorie dietary habits are prominent leading cause of metabolic
syndrome in modern world. Obesity plays a central role in occurrence of various diseases …

Diabetes mellitus type 2 is a world-wide growing health problem affecting more than 150
million people at the beginning of the new millennium. It is believed that this number will …