Context: Several interventions are available for the management of hypoxic ischemic
encephalopathy (HIE), but no studies have compared their relative efficacy in a single …

Objective: Therapeutic hypothermia (TH) is the current standard of care for neonatal hypoxic-
ischemic encephalopathy (HIE), yet morbidity and mortality remain significant. Adjuvant …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Objectives Neonatal hypoxic-ischemic encephalopathy is a major cause of perinatal death
and neurodevelopmental impairment (NDI). Hypothermia (HT) is the standard of care; …

Background We investigated the safety of therapeutic hypothermia during intervention in
infants with hypoxic-ischemic encephalopathy (HIE). Methods The MEDLINE, EMBASE …

Therapeutic hypothermia (TH) is now well established as the standard of care treatment for
moderate to severe neonatal encephalopathy secondary to perinatal hypoxic ischemic …

Hypothermia is a potential neuroprotective intervention to treat neonatal post-asphyxial
(hypoxic–ischemic) encephalopathy (HIE). In this meta-analysis of 13 clinical trials …

Background The objective of this study was to systematically review randomized trials
assessing therapeutic hypothermia as a treatment for term neonates with hypoxic ischemic …

Around 0.75 million babies worldwide suffer from moderate or severe hypoxic-ischemic
encephalopathy (HIE) each year resulting in around 400,000 babies with …

Background Although therapeutic hypothermia improves the outcome of neonatal hypoxic-
ischemic encephalopathy (HIE), its efficacy is still limited. This preliminary study evaluates …