A hallmark of eukaryotic cells is their separation into compartments. These compartments
are surrounded by membranes that are impermeable to macromolecules. As most proteins …

In eukaryotic cells, there is continuous exchange of macromolecules between the
nucleoplasm and the cytoplasm. Transport in both directions occurs through nuclear pore …

Protein Import into the Nucleus: An Integrated View Page 1 AnnlL Rev. Cell Dev. Bioi. 1995.
11:J55...Jl8 Copyright Q 1995 by Annual Reviews Inc. All rights reserved PROTEIN IMPORT …

To enter the nucleus, a protein must transit through one of the largest and most complex
gateways in the eukary-otic cell, the nuclear pore. Consisting of perhaps 1000 proteins (60 …

Our understanding of protein export from the nucleus to the cytoplasm has been advanced
recently by the discovery of active, signal-mediated export pathways. Nuclear export signals …

Several nuclear proteins, including steroid hormone receptors, have been shown to shuttle
continuously between the nucleus and the cytoplasm. The mechanism of entry of proteins …

The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell
offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear …

To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear
pore complex or it must be small enough to pass through by diffusion. Although these …

One of the most profound differences between prokaryotes and eukaryotes is that only the
latter segregate RNA synthesis and protein synthesis into distinct cellular compartments, ie …

Transport between the nucleus and cytoplasm involves both stationary components and
mobile factors acting in concert to move macromolecules through the nuclear pore complex …