Discovery, Topo I inhibitory activity and mechanism evaluation of two novel cytisine-type alkaloid dimers from the seeds of Sophora alopecuroides L

C Meng, Y Wang, S Chen, M Li, C Yuan… - Bioorganic & Medicinal …, 2022 - Elsevier
Abstract Alopecurosines A and B (CMs 1 and 2, respectively) are two novel cytisine-type
alkaloid dimers first isolated from the aerial parts of Sophora alopecuroides L. CMs 1 and 2 …

Alopecuroidines A− C, three matrine-derived alkaloids from the seeds of Sophora alopecuroides

X Yuan, Z Li, Z Feng, J Jiang, Y Yang, P Zhang - Chinese Chemical Letters, 2021 - Elsevier
Three matrine-derived alkaloids, alopecuroidine A (1), alopecuroidine B (2a) and
alopecuroidine C (2b) were isolated from the seeds of Sophora alopecuroides. Their …

Rapid Screening of Active Components with Topoisomerase I Inhibitory Activity in Sophora alopecuroides L. Based on Ultrafiltration Coupled with UPLC-QTOF-MS

L Zhang, X Yin, X Wan, Y Sun, M Cao… - Current …, 2022 - ingentaconnect.com
Background: Topoisomerase I (Topo I) is a key target of many antitumor drugs in vivo.
Alkaloids in Sophora alopecuroides L. can reportedly inhibit Topo I activity, but the …

A novel alkaloid from the seeds of Sophora alopecuroides L

ZJ Rong, XX Gao, GS Hu, T Yan, JM Jia… - Natural Product …, 2022 - Taylor & Francis
A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of
Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3', 5'-di …

Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis

XN Li, ZQ Lu, S Qin, HX Yan, M Yang, SH Guan, X Liu… - Tetrahedron …, 2008 - Elsevier
Tonkinensines A (1) and B (2), two novel cytisine-type alkaloids that feature the skeleton
with a linkage to pterocarpan, were isolated from the roots of Sophora tonkinensis. Their …

Three new alkaloids from the roots of Sophora tonkinensis

C Wu, L He, X Yi, J Qin, Y Li, Y Zhang… - Journal of natural …, 2019 - Springer
A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with
two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensi s. The …

Chemical Constituents and Their Activities From the Seeds of Ormosia hosiei

H Xu, Y Qiu, J Chen, Y Shi, X Zhang… - Natural Product …, 2019 - journals.sagepub.com
A new cytisine-like alkaloid, hosimonoal (1), with a fused monoterpene group, and 6 known
compounds (2-6) were isolated from the seeds of Ormosia hosiei Hemsl. et Wils. The …

Alkaloids from the roots of Sophora flavescens and their anti-tumor activity

Y Xu, X Wang, K Sa, H Li, L Chen - Fitoterapia, 2023 - Elsevier
Sophora flavescens belongs to Sophora genus of Leguminosae. Its roots are used as a
traditional Chinese medicine. In our study on Sophora flavescens roots, 3 new and 19 …

Alopecines A–E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides

XF Wang, Z Zhu, TT Hao, QQ Fang, K Jiang, SJ Qu… - Bioorganic …, 2020 - Elsevier
Abstract Alopecines A–E (1–5), five unusual matrine-type alkaloids featuring with an
additional dichlorocyclopropane (1–3) or a di/tri-chloromethyl (4/5) attached on the D ring …

Alopecuroides A–E, Matrine-Type Alkaloid Dimers from the Aerial Parts of Sophora alopecuroides

CL Fan, YB Zhang, Y Chen, P Xie… - Journal of natural …, 2019 - ACS Publications
Five new matrine-type alkaloid dimers, alopecuroides A–E, were isolated from the aerial
parts of Sophora alopecuroides. Alopecuroides A and B represent the first dimeric matrine …