Five new matrine-type alkaloid dimers, alopecuroides A–E, were isolated from the aerial
parts of Sophora alopecuroides. Alopecuroides A and B represent the first dimeric matrine …

The clinical application of mitoxantrone (MTZ), a DNA-intercalating topoisomerase II (topo II)
poison, has been largely limited by the risk of secondary tumor and severe …

Isoaurostatin A (IAS-A) isolated from Thermomonospora alba showed weak inhibition
against topoisomerase (topo) I (IC50= 307μM). To get more strong inhibition, derivatives of …

Abstract Novel tetracyclic pyrazolo [1, 5-a] pyrimidine derivatives; namely benzo [3, 4]
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …

Two series of new benzimidazole derivatives were designed and synthesized. The
antiproliferative activity of the new derivatives was screened against five human cancer cell …

Chemical studies of the Chinese herb Corydalis saxicola Bunting led to the isolation and
identification of 14 alkaloids, 1–14. Seven of these compounds, 4–9 and 11, were obtained …

A new matrine-type alkaloid, 7α-hydroxysophoramine (1), was isolated from the aerial parts
of Sophora alopecuroides together with eight known alkaloids, 12β-hydroxysophocarpine …

Six undescribed alkaloids together with 15 known alkaloids were isolated from the aerial
parts of Aconitum carmichaelii. Their structures were elucidated extensively by NMR and …

Abstract Three new quinolizidine alkaloids (1− 3), including one new naturally isoflavone
and cytisine polymer (3), along with 6 known ones were isolated from the ethanol extract of …

A phytochemical investigation on the alkaloid fractions of Sophora alopecuroides L. led to
the production of 11 undescribed matrine-type alkaloids, sophaloseedlines I–S (1− 11), 12 …