Quinolizidine alkaloids from Sophora alopecuroides with anti-inflammatory and anti-tumor properties

JC Li, WF Dai, D Liu, ZJ Zhang, MY Jiang, KR Rao… - Bioorganic …, 2021 - Elsevier
Abstract Forty-three quinolizidine alkaloids (1–43), including twelve new matrine-type ones,
sophalodes A–L (1–7, 17, 19 and 28–30), were isolated from the seeds of Sophora …

Cytotoxic aporphine alkaloids from Ocotea acutifolia

FR Garcez, AGF da Silva, WS Garcez, G Linck… - Planta …, 2011 - thieme-connect.com
Abstract Two new aporphinoid alkaloids,(+)-6S-ocoteine N-oxide and (+)-norocoxylonine,
were isolated from the leaves and trunk bark of Ocotea acutifolia (Lauraceae) along with …

Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II

S Wada, R Tanaka - Bioorganic & medicinal chemistry letters, 2005 - Elsevier
DNA topoisomerase (Topo) II is one of the target enzymes for chemotherapeutic drug
development. Lanostane-type triterpenoids with various functional groups (–Cl,–Br,–OMe …

Solanidane and iminosolanidane alkaloids from Solanum campaniforme

MCM Torres, RJB Jorge, RM Ximenes, NTQ Alves… - Phytochemistry, 2013 - Elsevier
From the leaves of Solanum campaniforme (Solanaceae), eight solanidane alkaloids were
isolated, four of which contain a p-hydroxyphenylethylamine unit. Their structures were …

A review on shikonin and its derivatives as potent anticancer agents targeted against topoisomerases

OZ Olatunde, J Yong, C Lu… - Current Medicinal …, 2024 - ingentaconnect.com
The topoisomerases (TOPO) play indispensable roles in DNA metabolism, by regulating the
topological state of DNA. Topoisomerase I and II are the well-established drug-targets for the …

[HTML][HTML] Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects

D Luo, Z Tu, W Yin, C Fan, N Chen, Z Wu… - Frontiers in …, 2021 - frontiersin.org
Four new alkaloids (1–4) belonging to rare examples of bis-amide matrine-type were
isolated from the seeds of sophora alopecuroides. Their structures including absolute …

Structurally Diverse Matrine‐Based Alkaloids with Anti‐inflammatory Effects from Sophora alopecuroides

D Luo, NH Chen, WZ Wang, JH Zhang… - Chinese Journal of …, 2021 - Wiley Online Library
Main observation and conclusion A phytochemical investigation on the seeds of Sophora
alopecuroides led to obtaining fourteen structurally diverse matrine‐based alkaloids (1 …

A novel skeleton alkaloid from Portulaca oleracea L. and its bioactivities

X Lan, S Guo, Y Zhao, M Zhang, D Zhang, A Leng… - Fitoterapia, 2023 - Elsevier
A novel skeleton alkaloid was obtained from Portulaca oleracea L., which was identified as
10, 11-dihydroxybenzo [5′, 6′] pentaleno [1′, 2′: 3, 4] pyrrolo [2, 1-b] oxazol-7 (11bH) …

Integrated analysis of topoisomerase I inhibitors from flavonoids of Scutellaria baicalensis Georgi using bioaffinity ultrafiltration UPLC-TripleTOF MS/MS, molecular …

N Tan, J Hu, H Wang, T Chen, D Duan, J Qi, X Wang… - Fitoterapia, 2023 - Elsevier
Scutellaria baicalensis Georgi (SBG) has been widely used as medical plant in East Asia
with remarkable anti-cancer activity. However, the underlying mechanisms are still confused …

A new bioactive coumestan from the seeds of Psoralea corylifolia

MY Chai - Journal of Asian Natural Products Research, 2019 - Taylor & Francis
A new coumestan named bavacoumestan D (1), together with five known compounds (2-6),
was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures …