GlgA plays an important role in the induction of hydrosalpinx by Chlamydia muridarum

C Hu, H Wu, Y Sun, J Kong, LL Shao… - Pathogens and …, 2020 - academic.oup.com
While glycogen synthase A deficiency can reduce the growth and proliferation of Chlamydia
muridarum, the effect of glycogen synthase A on the pathogenic process of C. muridarum …

Gut dysbiosis contributes to chlamydial induction of hydrosalpinx in the upper genital tract

Q Tian, T Zhang, L Wang, J Ma, X Sun - Frontiers in Microbiology, 2023 - frontiersin.org
Chlamydia trachomatis is one of the most common sexually infections that cause infertility,
and its genital infection induces tubal adhesion and hydrosalpinx. Intravaginal Chlamydia …

Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum

L Lei, J Chen, S Hou, Y Ding, Z Yang, H Zeng… - Infection and …, 2014 - Am Soc Microbiol
Plasmid-free Chlamydia trachomatis and Chlamydia muridarum fail to induce severe
pathology. To evaluate whether the attenuated pathogenicity is due to insufficient infection …

Intrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating …

J Chen, Z Yang, X Sun, L Tang, Y Ding… - Infection and …, 2015 - Am Soc Microbiol
Intravaginal infection with plasmid-competent but not plasmid-free Chlamydia muridarum
induces hydrosalpinx in mouse upper genital tract, indicating a critical role of the plasmid in …

Oviduct Infection and Hydrosalpinx in DBA1/j Mice Is Induced by Intracervical but Not Intravaginal Inoculation with Chlamydia muridarum

L Tang, H Zhang, L Lei, S Gong, Z Zhou, J Baseman… - PloS one, 2013 - journals.plos.org
Intravaginal infection with C. muridarum in mice often results in hydrosalpinx similar to that
found in women urogenitally infected with C. trachomatis, making the C. muridarum lower …

Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

Y Liu, Y Huang, Z Yang, Y Sun, S Gong… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …

Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx

Y Huang, Q Zhang, Z Yang, T Conrad, Y Liu, G Zhong - PloS one, 2015 - journals.plos.org
We have previously shown that the plasmid-encoded Pgp3 is a major virulence factor for C.
muridarum induction of hydrosalpinx. We now report that Pgp5 also plays a significant role …

Chlamydia trachomatis GlgA Is Secreted into Host Cell Cytoplasm

C Lu, L Lei, B Peng, L Tang, H Ding, S Gong, Z Li… - Plos one, 2013 - journals.plos.org
Glycogen has been localized both inside and outside Chlamydia trachomatis organisms. We
now report that C. trachomatis glycogen synthase (GlgA) was detected in both chlamydial …

A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains

Z Zhou, N Liu, Y Wang, AW Emmanuel… - Pathogens and …, 2019 - academic.oup.com
Objective This study is to investigate the functions of newly discovered genes in Chlamydia
muridarum (C. muridarum) strains with single gene differences. Methods Using whole …

The Structural Integrity of Plasmid-Encoded Pgp3 Is Essential for Induction of Hydrosalpinx by Chlamydia muridarum

Y Huang, Y Sun, T Qin, Y Liu - Frontiers in Cellular and Infection …, 2019 - frontiersin.org
Pgp3 consists of globular N-and C-terminal domains connected by a triple-helical coiled-coil
middle domain. We demonstrated previously that Pgp3 is required for induction of …