Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity

S Voringer, L Schreyer, W Nadolni, MA Meier… - Oncogene, 2020 - nature.com
Myocardin-related transcription factors A and B (MRTFs) are coactivators of Serum
Response Factor (SRF) that mediates the expression of genes involved in cell proliferation …

TRPM8 inhibition regulates the proliferation, migration and ROS metabolism of bladder cancer cells

G Wang, R Cao, K Qian, T Peng, L Yuan… - OncoTargets and …, 2020 - Taylor & Francis
Introduction Based on accumulating evidence, transient receptor potential (TRP) ion
channels may play important roles in the occurrence and the progression of cancer. TRP …

TRPM8: a potential target for cancer treatment

Z Liu, H Wu, Z Wei, X Wang, P Shen, S Wang… - Journal of cancer …, 2016 - Springer
Transient receptor potential (TRP) cation channel superfamily plays critical roles in variety of
processes, including temperature perception, pain transduction, vasorelaxation, male …

TRPM2 in Cancer

BA Miller - Cell Calcium, 2019 - Elsevier
The TRP ion channel TRPM2 has an essential function in cell survival and protects the
viability of a number of cell types after oxidative stress. It is highly expressed in many …

TRPM2-AS promotes cancer cell proliferation through control of TAF15

L Pan, Y Li, L Jin, J Li, A Xu - The international journal of biochemistry & …, 2020 - Elsevier
Background Colorectal cancer (CRC) ranks the third among all common malignancy
worldwide. Long noncoding RNAs (lncRNAs) have been demonstrated as implicated in …

[HTML][HTML] Roles of TRPM7 in ovarian cancer

ZB Wang, X Zhang, F Xiao, ZQ Liu, QJ Liao… - Biochemical …, 2023 - Elsevier
Ovarian cancer stands as the prevailing gynecologic malignancy, afflicting over 313,959
individuals annually worldwide, accompanied by more than 207,252 fatalities. Perturbations …

TRPM7 regulates AKT/FOXO1–dependent tumor growth and is an independent prognostic indicator in renal cell carcinoma

Z Zhao, M Zhang, X Duan, Y Chen, E Li, L Luo… - Molecular Cancer …, 2018 - AACR
Transient receptor potential melastatin 7 (TRPM7) is important for the tumorigenesis and
progression of several cancers. However, little is known about TRPM7 expression and its …

[PDF][PDF] TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.

S Almasi, C Yu Long, A Sterea… - … Press GmbH & …, 2019 - articles.cellphysiolbiochem.com
Abstract Background/Aims: The oxidative stress sensor transient receptor potential
melastatin-2 (TRPM2) ion channel has recently gained attention in many types of cancer …

[HTML][HTML] Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway

R Cao, Z Meng, T Liu, G Wang, G Qian, T Cao… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Transient receptor potential melastatin 7 (TRPM7) functions as a Mg 2+/Ca 2+-permeable
channel fused with a kinase domain and regulates various physical processes and …

TRPM8 facilitates proliferation and immune evasion of esophageal cancer cells

X Lan, J Zhao, C Song, Q Yuan, X Liu - Bioscience Reports, 2019 - portlandpress.com
Esophageal cancer is seen with increasing incidence, but the underlying mechanism of
esophageal cancer is still unknown. Transient receptor potential melastatin (TRPM) is non …