[HTML][HTML] IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
KL Jønsson, A Laustsen, C Krapp, KA Skipper… - Nature …, 2017 - nature.com
Innate immune activation by macrophages is an essential part of host defence against
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …
[HTML][HTML] A new cytosolic DNA-recognition pathway for DNA-induced inflammatory responses
J Meng, X Liu, X Cao - Cellular & Molecular Immunology, 2014 - nature.com
Innate recognition of DNA within intracellular compartments or the cytoplasm leads to
activation of the immune system, which can result in defense against DNA virus infections or …
activation of the immune system, which can result in defense against DNA virus infections or …
[引用][C] IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun 8: 14391
KL Jønsson, A Laustsen, C Krapp, KA Skipper… - 2017
[HTML][HTML] IFI16 is an innate immune sensor for intracellular DNA
L Unterholzner, SE Keating, M Baran, KA Horan… - Nature …, 2010 - nature.com
The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …
[HTML][HTML] DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice
W Chen, SX Yu, FH Zhou, XJ Zhang, WY Gao… - Frontiers in …, 2019 - frontiersin.org
Interferon-inducible protein (IFI204)(p204, the murine homolog of human IFI16) is known as
a cytosolic DNA sensor to recognize DNA viruses and intracellular bacteria. However, little is …
a cytosolic DNA sensor to recognize DNA viruses and intracellular bacteria. However, little is …
[HTML][HTML] IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
JF Almine, CAJ O'Hare, G Dunphy, IR Haga… - Nature …, 2017 - nature.com
Many human cells can sense the presence of exogenous DNA during infection though the
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
MH Orzalli, NM Broekema, BA Diner… - Proceedings of the …, 2015 - National Acad Sciences
Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been
proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and …
proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and …
Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity
Deregulated innate immune responses that result in increased levels of type I interferons
(IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic …
(IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic …
Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA
JL Shannon, MS Murphy, U Kantheti, JM Burnett… - Molecular …, 2018 - Elsevier
Recent studies have highlighted the importance of immune sensing of cytosolic DNA of both
pathogen and host origin. We aimed to examine the role of DNA sensors interferon-γ …
pathogen and host origin. We aimed to examine the role of DNA sensors interferon-γ …
[HTML][HTML] TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical
for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor …
for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor …