Background/Purpose: Aggressive tumors may alter their expression of Bcl-2 proteins to
decrease apoptosis and increase survival. The authors reported previously that …

Background. The dysregulation of apoptosis may alter the progression of tumor growth and
explain the clinical dichotomy observed in children with neuroblastoma (NB). An …

Bcl-2 protooncogene, originally discovered at the chromosomal breakpoint of the t (14; 18)
in follicular lymphoma, is known to regulate the process of programmed cell death or …

Background/Purpose: Aggressive neuroblastomas avoid apoptosis and have increased
expression of the antiapoptotic protein, Bcl-2. Insulin-like growth factor-I (IGF-I) is mitogenic …

Background The expression of bcl-2 is associated with suppression of programmed cell
death and prolonged cell survival. Recently, immunoreactivity to the bcl-2 gene product has …

Apoptosis is the selective physiologic deletion of cells that are no longer required. Over‐
expression of the bcl‐2 protooncogene extends survival of neurons otherwise destined for …

Survival rate in neuroblastoma, a tumor of post-ganglionic sympathetic neuroblasts,
correlates with disease stage, tumor histology, and N-myc gene amplification. N-myc …

Neuroblastoma (NB) is a tumor of the sympathetic nervous system which develops in young
children. It derives from cells of the embryonal neural crest that form many different tissues …

Purpose: Apoptosis plays a crucial role in normal development and mediates tumor
response to chemotherapy. This study investigated the pattern of apoptotic gene expression …

Spontaneous regression occurs in some cases of neuroblastoma, especially stage IVS. The
incidence of neuroblastoma has been reported to be increasing since the mass screening …