Cancers develop complex and dynamic tissue microenvironments to support their sustained
growth, invasion and metastasis. For decades, rapid progress has been made in the cross …

Recent work has suggested involvement of the immune system in biological therapies
specifically targeting tumor microenvironment. Substantial advancement in the treatment of …

Tumor immune microenvironment is a very complex system that is influenced by a wide
range of factors; in this microenvironment, various immune cells, stromal cells, and cytokines …

Accumulating evidence indicates that a dynamic cross-talk between tumors and the immune
system can regulate tumor growth and metastasis. Increased understanding of the …

Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint
inhibitors as especially promising candidates for cancer therapy. However, some issues …

The cross talk between immune and non-immune cells in the tumor microenvironment leads
to immunosuppression, which promotes tumor growth and survival. Immunotherapy is an …

Unlike traditional cancer therapies, such as surgery, radiation and chemotherapy that are
typically non-specific, cancer immunotherapy harnesses the high specificity of a patient's …

Cancer immunotherapy, including immune checkpoint blockade and CAR-T cell therapy,
has introduced revolutionary approaches to treating patients with cancer. The success and …

Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

There is much promise in the use of immunotherapy for the treatment of cancer. Approaches
such as those using antibodies or adoptive cell transfer can mediate complete tumor …