Objective We have reported that bradykinin (BK) excretion is increased in severely diabetic
rats, independent of the activity of the main renal kininforming enzyme, true kallikrein (KLK) …

A reduction of renal kallikrein has been found in non-insulin-treated diabetic individuals,
suggesting that an impaired renal kallikrein-kinin system (KKS) contributes to the …

Emerging evidence suggests a role of the kallikrein-kinin system (KKS) in the pathogenesis
of diabetic nephropathy (DN). Tissue kallikrein 1 is a member of the tissue kallikrein family …

Urinary and renal rK1-kallikrein was studied in spontaneously hypertensive rats (SHR) and
their normotensive controls (WKY). It was demonstrated that the antiserum used for kallikrein …

The renal kallikrein-kinin system (RKKS) has been related to blood pressure control and
sodium and water balance. We have previously shown that female spontaneously …

The renal kallikrein-kinin system is thought to participate in blood pressure regulation and
displays abnormalities in human hypertension, as well as in many animal models of …

Cardiovascular diseases are the most common causes of mortality worldwide. Hypertension
and diabetes are the two major risk factors in the development of cardiac hypertrophy …

Tissue kallikrein (KLK1) is a kinin-forming serine protease synthesized in many organs
including arteries and kidney. Study of the physiological role of KLK1 has benefited from the …

Renal kallikrein is increased in diabetic patients and streptozotocin (STZ)-induced diabetic
rats with hyperflltration. Chronic inhibition of renal kallikrein reduces glomerular filtration rate …

Kallikreins are serine proteases that release kinins from kininogens. Kinins, via their effects
on cardiovascular and renal function, may be involved in the pathogenesis of hypertension …