There is a marked decrease in the prevalence and extent of high-grade prostatic
intraepithelial neoplasia (PIN) in men with prostate cancer after androgen deprivation …

Prostatic intraepithelial neoplasia (PIN) is composed of dysplastic cells with a luminal cell
phenotype, expressing the androgen receptor as well as prostate‐specific antigen. PIN is …

Objectives: To evaluate the potential application of chemoprevention strategies in prostatic
intraepithelial neoplasia. Methods: Review of relevant literature on chemoprevention with …

Background. Leuprolide, an agonist of luteinizing hormone‐releasing hormone (LH‐RH),
and flutamide, an antiandrogen, increasingly are being used in the treatment of clinically …

Maximal androgen blockade (MAB), combining a luteinizing hormone releasing hormone
(LHRH) agonist and a pure or non-steroidal anti-androgen, induces significant morphologic …

Thanks to earlier detection of clinically significant prostatic adenocarcinoma by
measurement of serum prostate-specific antigen (PSA) levels, increasing numbers of …

Prostatic intraepithelial neoplasia (PIN) is composed of dysplastic cells with a luminal cell
phenotype, expressing the androgen receptor as well as prostate specific antigen. PIN is …

Correspondence Page 1 Correspondence Primary urethral transitional cell carcinoma in a
female Sir, I was particularly interested in this paper [1]; we published our experiences of 10 …

Several retrospective studies, as well as prospective trials, have demonstrated that
neoadjuvant total androgen ablation therapy leads to involutional changes in prostatic …

The most efficient strategy for chemoprevention clinical trials are short‐term studies which
focus on surrogate endpoint biomarkers (SEBs) in high‐risk target populations. High‐grade …